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4-hydroxyacetophenone degradation
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PWY-7002
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4-hydroxyphenylacetate hydrolase|4-hydroxyacetophenone monooxygenase|hydroquinone 1,2-dioxygenase|4-hydroxyphenylacetate hydrolase hapB
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acetate|NADPH|2-maleylacetate|H2O|NADP+|4-hydroxyphenylacetate|4-hydroxyacetophenone|(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate|H+|3-oxoadipate|NAD+|benzene-1,4-diol|NADH|oxygen
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1
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4-nitrophenol degradation I
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PWY-5487
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maleylacetate reductase|4-nitrophenol 4-monooxygenase pnpA|hydroquinone dioxygenase|4-benzoquinone reductase|4-benzoquinone reductase [PnpB]2|4-nitrophenol 4-monooxygenase|4-hydroxymuconic-semialdehyde dehydrogenase|hydroquinone 1,2-dioxygenase
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H2O|NADPH|2-maleylacetate|NADP+|nitrite|4-nitrophenol|(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate|H+|3-oxoadipate|NAD+|1,4-benzoquinone|benzene-1,4-diol|NADH|oxygen
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1
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ADP-L-glycero-β-D-manno-heptose biosynthesis
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PWY0-1241
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D-sedoheptulose 7-phosphate isomerase|fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [RfaE]2|D,D-heptose 1,7-bisphosphate phosphatase|ADP-L-glycero-D-mannoheptose-6-epimerase|fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase|ADP-L-glycero-D-mannoheptose-6-epimerase [RfaD]5|D,D-heptose 1,7-bisphosphate phosphatase gmhB
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H2O|D-glycero-β-D-manno-heptose 1,7-bisphosphate|D-glycero-β-D-manno-heptose 1-phosphate|ADP-D-glycero-β-D-manno-heptose|D-glycero-D-manno-heptose 7-phosphate|diphosphate|ADP-L-glycero-β-D-manno-heptose|D-sedoheptulose 7-phosphate|H+|phosphate
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1
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ajmaline and sarpagine biosynthesis
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PWY-5301
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raucaffricine glucosidase|polyneuridine aldehyde esterase|vinorine synthase|raucaffricine glucosidase RG|acetylajmalan esterase|polyneuridine aldehyde esterase PNAE|deoxysarpagine hydroxylase|vinorine 21-hydroxylase|vinorine synthase VS|vellosimine reductase|strictosidine glucosidase|vomilenine reductase|strictosidine glucosidase [SGR1]|1,2-dihydrovomilenine reductase
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S-adenosyl-L-methionine|polyneuridine aldehyde|NADPH|methanol|16-epivellosimine|1,2-dihydrovomilenine|raucaffricine|vomilenine|17-O-acetylnorajmaline|H2O|vinorine|acetyl-CoA|17-O-acetylajmaline|NADP+|geissoschizine|ajmaline|10-deoxysarpagine|acetate|sarpagine|UDP-α-D-glucose|strictosidine|4,21-dehydrogeissoschizine|vellosimine|oxygen|coenzyme A|CO2|norajmaline|H+|S-adenosyl-L-homocysteine|strictosidine-aglycone
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1
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benzoyl-CoA degradation II (anaerobic)
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CENTBENZCOA-PWY
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β-oxoacyl-CoA hydrolase|cyclohexa-1,5-diene-1-carboxyl-CoA hydratase|benzoyl-CoA reductase|6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase|6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase [Had]2
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glutaryl-CoA|H2O|NAD+|3-oxopimeloyl-CoA|acetyl-CoA|cyclohex-1,5-diene-1-carbonyl-CoA|6-oxocyclohex-1-ene-1-carbonyl-CoA|benzoyl-CoA|H+|phosphate|3-hydroxypimeloyl-CoA|NADH|coenzyme A
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1
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bile acid biosynthesis, neutral pathway
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PWY-6061
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bile acid-CoA:amino acid N-acyltransferase|bile acid CoA ligase|cytochrome P450 8B1 CYP8B1|sterol carrier protein 2|Δ4-3-oxosteroid 5β-reductase Akr1d1|3α-hydroxysteroid dehydrogenase (A-specific)|sterol carrier protein 2 Scp2|bile acid CoA ligase Slc27a5|bile acid-CoA:amino acid N-acyltransferase Baat|peroxisomal acyl-coenzyme A oxidase 2|3β-hydroxy-Δ5-C27 steroid oxidoreductase|cytochrome P450 27A1|cytochrome P450 27A1 Cyp27a1|peroxisomal multifunctional enzyme type 2 [Hsd17b4]2|peroxisomal multifunctional enzyme type 2|3β-hydroxy-Δ5-C27 steroid oxidoreductase Hsd3b7|Δ4-3-oxosteroid 5β-reductase|cytochrome P450 7A1|3α-hydroxysteroid dehydrogenase (A-specific) Akr1c9|very long-chain acyl-CoA synthetase|cytochrome P450 8B1|α-methylacyl-CoA racemase
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(25S)-3α,7α-dihydroxy-5β-cholestanoyl-CoA|NADPH|glycine|(25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate|cholesterol|(25R)-3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA|5β-cholestane-3α,7α,12α-triol|(25R)-5β-cholestane-3α,7α,26-triol|(25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-al|H2O|NAD+|(24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl CoA|5β-cholestane-3α,7α-diol|NADP+|(24E)-3α,7α-dihydroxy-5β-cholest-24-enoyl-CoA|(25R)-3α,7α-dihydroxy-5β-cholestan-26-al|7α-hydroxycholesterol|(25R)-3α,7α-dihydroxy-5β-cholestanoyl-CoA|taurine|7α-hydroxycholest-4-en-3-one|H+|(24E)-3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA|(25R)-3α,7α-dihydroxy-5-β-cholestanate|7α,12α-dihydroxycholest-4-en-3-one|propanoyl-CoA|choloyl-CoA|oxygen|coenzyme A|7α,12α-dihydroxy-5β-cholestan-3-one|glycocholate|(25R)-5β-cholestane-3α,7α,12α,26-tetraol|taurocholate|glycochenodeoxycholate|(24R,25R)-3α,7α,24-trihydroxy-5β-cholestanoyl CoA|NADH|(25S)-3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA|3α,7α,12α-trihydroxy-24-oxo-5-β-cholestanoyl CoA|chenodeoxycholoyl-CoA|7α-hydroxy-5β-cholestan-3-one|taurochenodeoxycholate|diphosphate|3α,7α-dihydroxy-24-oxo-5β-cholestanoyl CoA
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1
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butirosin biosynthesis
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PWY-7019
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[BtrI acyl-carrier protein]--L-glutamate ligase btrJ|4-(L-γ-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase|[BtrI acyl-carrier protein]--L-glutamate ligase|L-glutamyl-[BtrI acyl-carrier protein] decarboxylase [BtrK]2|γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase|ribostamycin:(S)-2-hydroxy-4-glutamyl-4-aminobutanoyl-[BtrI acyl-carrier protein] (S)-2-hydroxy-4-glutamyl-4-aminobutanoate transferase|4-(L-γ-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase btrO|ribostamycin:(S)-2-hydroxy-4-glutamyl-4-aminobutanoyl-[BtrI acyl-carrier protein] (S)-2-hydroxy-4-glutamyl-4-aminobutanoate transferase btrH|L-glutamyl-[BtrI acyl-carrier protein] decarboxylase|γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase btrG
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ribostamycin|H2O|5-oxo-L-proline|butirosin A|γ-L-glutamyl-butirosin B|L-glutamate|butirosin B|H+|FMNH2|phosphate|CO2|oxygen
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1
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catecholamine biosynthesis
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PWY66-301
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dopamine β-monooxygenase [DBH]4|phenylethanolamine N-methyltransferase PNMT|phenylethanolamine N-methyltransferase|dopamine β-monooxygenase|aromatic L-amino acid decarboxylase|tyrosine 3-monooxygenase
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S-adenosyl-L-methionine|dopamine|H2O|L-dopa|L-tyrosine|(R)-adrenaline|(R)-noradrenaline|L-ascorbate|H+|L-dehydro-ascorbate|S-adenosyl-L-homocysteine|4α-hydroxy-tetrahydrobiopterin|CO2|oxygen
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1
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cholesterol biosynthesis I
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PWY66-341
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lanosterol synthase|cytochrome P450 51A1|3-keto-steroid reductase|lamin B receptor|3-β-hydroxysteroid-Δ8-Δ7-isomerase|3-β-hydroxysteroid-Δ8-Δ7-isomerase [EBP]4|24-dehydrocholesterol reductase precursor|squalene monooxygenase|Δ 7-sterol reductase DHCR7|farnesyl-diphosphate farnesyltransferase|Δ 7-sterol reductase|C-4 methyl sterol oxidase|lathosterol oxidase SC5DL|NAD(P)-dependent 3β-hydroxy-4α-carboxy-sterol 3-dehydrogenase (decarboxylating)|24-dehydrocholesterol reductase precursor DHCR24|lathosterol oxidase
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14-hydroxylanosterol|NADPH|4α-carboxy-5α-cholesta-8,24-dien-3β-ol|zymosterol|4,4-dimethyl-cholesta-8,12,24-trienol|lathosterol|cholesterol|4,4-dimethylzymosterol|4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol|4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol|H2O|5α-cholesta-8,24-dien-3-one|(3S)-2,3-epoxy-2,3-dihydrosqualene|NADP+|4α-methyl-zymosterol|formate|CO2|4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol|3-dehydro-4-methylzymosterol|oxygen|diphosphate|14-oxolanosterol|squalene|5α-cholesta-7,24-dien-3β-ol|4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol|4α-formyl-5α-cholesta-8,24-dien-3β-ol|lanosterol|H+|7-dehydrocholesterol|(2E,6E)-farnesyl diphosphate
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1
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chondroitin sulfate biosynthesis
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PWY-6569
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chondroitin sulfate N-acetylgalactosaminyltransferase 2|chondroitin sulfate synthase 2|xylosylprotein 4-β-galactosyltransferase B4GALT7|β-1,3-galactosyltransferase 6 B3GALT6|chondroitin 6-O-sulfotransferase 1|galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase 2|chondroitin 4-sulfotransferase 2|xylosyltransferase 2|chondroitin sulfate synthase 1|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase|chondroitin sulfate synthase 3|xylosylprotein 4-β-galactosyltransferase|chondroitin 6-sulfotransferase 2|uronyl 2-sulfotransferase|chondroitin sulfate glucuronyltransferase|chondroitin 4-sulfotransferase 1|chondroitin 4-sulfotransferase 3|galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase 1|β-1,3-galactosyltransferase 6|galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase 3|chondroitin sulfate N-acetylgalactosaminyltransferase 1|xylosyltransferase 1
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N-acetyl-D-galactosaminyl-(1→4)-β-D-glucuronyl-(1→3)-β-N-acetyl-D-galactosaminyl-(1→4)-β-D-glucuronyl-(1→3)-β-D-galactosyl-(1->3)-β-D-galactosyl-(1->4)-β-D-xylosyl-core protein|UDP-N-acetyl-α-D-galactosamine|UDP-N-acetyl-D-galactosamine|3-phosphoadenylyl-sulfate|adenosine 3,5-bisphosphate|a core protein L-serine|UDP-α-D-glucuronate|H+|UDP-α-D-galactose|UDP-α-D-xylose
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1
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