|
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
|
PWY-7376
|
precorrin-3B synthase|precorrin-4 (C11)-methyltransferase cobM|precorrin-2 (C20)-methyltransferase|precorrin-2 (C20)-methyltransferase [CobI]2|precorrin 3B synthase|precorrin-8x methylmutase [CobH]2|uroporphyrin-III methyltransferase|precorrin-6B C5,15-methyltransferase|precorrin-6B C5,15-methyltransferase [CobL]8|cobyrinate a,c-diamide synthase [CobB]2|precorrin-3B (C17)-methyltransferase cobJ|precorrin-4 (C11)-methyltransferase|cobaltochelatase|precorrin-6A reductase|cobyrinate a,c-diamide synthase|precorrin-8x methylmutase|precorrin-5 (C1)-methyltransferase cobF|precorrin-5 (C1)-methyltransferase|precorrin-6A reductase cobK|cobaltochelatase [CobN][(CobS)(CobT)]|precorrin-3B (C17)-methyltransferase
|
precorrin-4|S-adenosyl-L-methionine|NADPH|L-glutamine|precorrin-6B|Co2+|H2O|hydrogenobyrinate a,c-diamide|NAD+|NADP+|cob(II)yrinate a,c-diamide|precorrin-2|L-glutamate|phosphate|CO2|acetate|precorrin-6A|precorrin-5|precorrin-1|precorrin-3B|precorrin-7|precorrin-8x|uroporphyrinogen-III|oxygen|precorrin-3A|hydrogenobyrinate|S-adenosyl-L-homocysteine|H+|NADH
|
9
|
|
NAD salvage pathway III
|
NAD-BIOSYNTHESIS-II
|
NAD pyrophosphatase|NadR DNA-binding transcriptional repressor and NMN adenylyltransferase|nicotinamide mononucleotide adenylyltransferase / ribosylnicotineamide kinase|acid phosphomonoesterase
|
H2O|β-nicotinamide D-ribonucleotide|NAD+|diphosphate|NADP+|H+|phosphate|1-(β-D ribofuranosyl)nicotinamide
|
9
|
|
nicotine degradation IV
|
PWY66-201
|
dimethylaniline monooxygenase (n-oxide forming) 3|UDP glycosyltransferase 1 family, polypeptide A4|indolethylamine N-methyltransferase|aldehyde oxidase|cytochrome P450 2A6|indolethylamine N-methyltransferase INMT|UDP glycosyltransferase 1 family, polypeptide A4 UGT1A4
|
S-adenosyl-L-methionine|NADPH|4-oxo-4-(3-pyridyl)-butanoate|4-(3-pyridyl)-3-butenoate|4-hydroxy-4-(3-pyridyl)-butanoate|4-(3-pyridyl)-butanoate|4-oxo-4-(pyridin-3-yl)butanal|4-oxo-4-(3-pyridyl)-butanamide|H2O|norcotinine|NADP+|2-hydroxynicotine|nicotine-1-N-oxide|nicotine isomethonium ion|UDP-α-D-glucuronate|pseudooxynicotine|methylamine|S-adenosyl-L-homocysteine|cotinine|hydrogen peroxide|oxygen|nicotine-glucuronide|nornicotine|3-pyridylacetate|formaldehyde|(S)-nicotine|nicotine-Δ15-iminium ion|H+
|
9
|
|
caffeine degradation III (bacteria, via demethylation)
|
PWY-6538
|
xanthine oxidase|xanthine dehydrogenase|7-methylxanthine demethylase|methylxanthine N3-demethylase [NdmD][NdmB]|methylxanthine N1-demethylase|methylxanthine N3-demethylase|caffeine demethylase|methylxanthine N7-demethylase|theobromine demethylase|methylxanthine N1-demethylase [NdmD][NdmA]
|
H2O|theobromine|NAD+|paraxanthine|7-methylxanthine|hydrogen peroxide|formaldehyde|urate|H+|xanthine|NADH|oxygen|caffeine
|
9
|
|
caffeine degradation IV (bacteria, via demethylation and oxidation)
|
PWY-6632
|
xanthine oxidase|methylxanthine N1-demethylase [NdmD][NdmA]|methylxanthine N3-demethylase [NdmD][NdmB]
|
H2O|theobromine|NAD+|paraxanthine|3,7-dimethylurate|7-methylxanthine|hydrogen peroxide|formaldehyde|urate|1,7-dimethylurate|7-methylurate|H+|xanthine|NADH|oxygen|caffeine
|
9
|
|
catechol degradation to 2-oxopent-4-enoate II
|
PWY-5419
|
catechol 2,3-dioxygenase|4-oxalocrotonate decarboxylase, subunit of 4-oxalocrotonate/2-oxopent-4-enoate hydratase complex|2-hydroxymuconate semialdehyde dehydrogenase|2-hydroxymuconate tautomerase
|
H2O|NAD+|2-oxopent-4-enoate|(2Z,4E)-2-hydroxyhexa-2,4-dienedioate|CO2|(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate|H+|(3E)-2-oxohex-3-enedioate|catechol|NADH|oxygen
|
9
|
|
coumarins biosynthesis (engineered)
|
PWY-7398
|
caffeoyl-CoA O-methyltransferase|4-coumarate 3-monooxygenase|phenylalanine/tyrosine ammonia-lyase|phenylalanine/tyrosine ammonia-lyase [PAL]4|4-coumarate 3-monooxygenase hpaB|4-coumarate coenzyme A ligase 2|4-coumarate--CoA ligase 1|4-coumarate coenzyme A ligase 1
|
S-adenosyl-L-methionine|FADH2|L-dopa|ammonium|6-hydroxyferuloyl-CoA|H2O|trans-caffeoyl-CoA|feruloyl-CoA|trans-caffeate|4-coumaroyl-CoA|2,4,6-trihydroxycinnamoyl-CoA|CO2|L-tyrosine|FAD|scopoletin|4-coumarate|2,4-dihydroxycinnamoyl-CoA|esculetin|succinate|oxygen|coenzyme A|umbelliferone|diphosphate|S-adenosyl-L-homocysteine|H+|2-oxoglutarate
|
9
|
|
glycocholate metabolism (bacteria)
|
PWY-6518
|
3α-hydroxysteroid dehydrogenase|12β-hydroxysteroid dehydrogenase|7β-hydroxysteroid dehydrogenase|12α-hydroxysteroid dehydrogenase [12α-hydroxysteroid dehydrogenase subunit]4|7α-hydroxysteroid dehydrogenase|NAD-dependent bile acid 3β-dehydrogenase|12α-hydroxysteroid dehydrogenase|choloylglycine hydrolase
|
cholate|H2O|NADPH|glycine|3-dehydrocholate|NADP+|3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate|glycocholate|isocholate|3α,7α,12β-trihydroxy-5β-cholan-24-oate|H+|NAD+|NADH|3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate|7-epicholate
|
9
|
|
glyoxylate assimilation
|
PWY-5744
|
malonyl-CoA reductase|β-methylmalyl-CoA dehydratase|mesaconyl-C4-CoA hydratase [Meh]2|acrylyl-CoA reductase (NADPH)|mesaconyl-C1-CoA-C4-CoA transferase|acetyl-CoA carboxylase complex|mesaconyl-C4-CoA hydratase|L-malyl CoA lyase|malonyl CoA reductase|propionyl-CoA synthase|mesaconyl-C1-CoA-C4-CoA transferase [Mct]2
|
H2O|NADPH|(2R,3S)-β-methylmalyl-CoA|acetyl-CoA|3-hydroxypropanoyl-CoA|propanoyl-CoA|diphosphate|NADP+|glyoxylate|hydrogen carbonate|3-methylfumaryl-CoA|acryloyl-CoA|2-methylfumaryl-CoA|(3S)-citramalyl-CoA|H+|phosphate|malonyl-CoA|pyruvate|3-hydroxypropanoate|3-oxopropanoate|coenzyme A
|
9
|
|
ipsdienol biosynthesis
|
PWY-7410
|
geranyl diphosphate synthase / myrcene synthase|myrcene hydroxylase|ipsdienol dehydrogenase IDOLDH
|
H2O|NADPH|dimethylallyl diphosphate|(4R)-(-)-ipsdienol|diphosphate|NADP+|isopentenyl diphosphate|(4S)-(+)-ipsdienol|H+|β-myrcene|geranyl diphosphate|oxygen
|
9
|