|
superpathway of erythromycin biosynthesis (without sugar biosynthesis)
|
PWY-6975
|
6-deoxyerythronolide B synthase [(EryA3)(EryA2)(EryA1)]2|6-deoxyerythronolide B 6S-monooxygenase eryF|6-deoxyerythronolide B 6S-monooxygenase|6-deoxyerythronolide B synthase|3-L-mycarosyl erythronolide B desosaminyltransferase complex|erythromycin C-12 monooxygenase|dTDP-L-mycarosyl: erythronolide B mycarosyltransferase eryBV|3-L-mycarosyl erythronolide B desosaminyltransferase complex [(EryCII)(EryCIII)]2|dTDP-L-mycarosyl: erythronolide B mycarosyltransferase|erythromycin C-12 monooxygenase eryK
|
S-adenosyl-L-methionine|erythronolide B|H2O|NADPH|dTDP-D-desosamine|dTDP-β-L-mycarose|(S)-methylmalonyl-CoA|erythromycin C|NADP+|6-deoxyerythronolide B|erythromycin D|S-adenosyl-L-homocysteine|3-α-mycarosylerythronolide B|erythromycin A|H+|propanoyl-CoA|erythromycin B|CO2|oxygen|coenzyme A
|
16
|
|
xylose degradation IV
|
PWY-7294
|
aldose 1-dehydrogenase [Gdh]4|2-dehydro-3-deoxy-D-arabinonate aldolase [multifunctional]|aldose 1-dehydrogenase|D-xylonate dehydratase|glycolaldehyde oxidoreductase|glycolaldehyde oxidoreductase [SSO2637][SSO2636][SSO2639]|malate synthase|glycolate dehydrogenase
|
D-xylonate|H2O|NAD+|acetyl-CoA|D-xylonolactone|glycolaldehyde|(S)-malate|H+|glyoxylate|glycolate|2-dehydro-3-deoxy-D-arabinonate|pyruvate|NADH|D-xylopyranose|coenzyme A
|
16
|
|
adenosylcobalamin salvage from cobinamide II
|
PWY-6269
|
adenosylcobalamin synthase|cob(I)alamin adenosyltransferase / cobinamide adenosyltransferase|adenosylcobinamide amidohydrolase|adenosylcobinamide-phosphate synthase|adenosylcobinamide hydrolase [multifunctional]|GTP:adenosylcobinamide-phosphate guanylyltransferase
|
α-ribazole 5-phosphate|cobinamide|H2O|adenosylcobyrate|(R)-1-aminopropan-2-ol|5,6-dimethylbenzimidazole|diphosphate|PPPi|nicotinate|adenosylcobinamide-GDP|(R)-1-amino-2-propanol O-2-phosphate|adenosylcobalamin 5-phosphate|H+|phosphate|adenosyl-cobinamide phosphate|adenosylcobinamide|β-nicotinate D-ribonucleotide
|
15
|
|
3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation
|
PWY0-1277
|
2,3-dihydroxyphenylpropionate 1,2-dioxygenase [MhpB]4|acetaldehyde dehydrogenase 2|3-phenylpropionate dioxygenase system [HcaC][HcaD][HcaF][HcaE]|2-hydroxypentadienoate hydratase|2,3-dihydroxyphenylpropionate 1,2-dioxygenase|2-hydroxy-6-oxononatrienedioate hydrolase [MhpC]2|4-hydroxy-2-ketovalerate aldolase|3-(3-hydroxyphenyl)propionate 2-hydroxylase|3-(3-hydroxyphenyl)propionate 2-hydroxylase mhpA|2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase|2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase hcaB|3-phenylpropionate dioxygenase system|2-hydroxy-6-oxononatrienedioate hydrolase
|
H2O|NAD+|acetyl-CoA|2-oxopent-4-enoate|succinate|3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate|(2Z)-2-hydroxypenta-2,4-dienoate|acetaldehyde|3-phenylpropanoate|3-(3-hydroxyphenyl)propanoate|(2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate|H+|3-(2,3-dihydroxyphenyl)propanoate|4-hydroxy-2-oxopentanoate|pyruvate|NADH|oxygen|coenzyme A
|
15
|
|
ergothioneine biosynthesis I (bacteria)
|
PWY-7255
|
γ-glutamyl-hercynylcysteine sulfoxide hydrolase egtC|hercynine oxygenase|glutamate—cysteine ligase|hercynylcysteine S-oxide lyase|γ-glutamyl-hercynylcysteine sulfoxide hydrolase|hercynine oxygenase egtB|L-histidine Nα-methyltransferase
|
S-adenosyl-L-methionine|L-cysteine|H2O|γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide|ammonium|L-histidine|ergothioneine|S-(hercyn-2-yl)-L-cysteine S-oxide|L-glutamate|H+|hercynine|phosphate|ergothioneine (thione form)|pyruvate|S-adenosyl-L-homocysteine|oxygen
|
15
|
|
erythromycin D biosynthesis
|
PWY-7106
|
6-deoxyerythronolide B synthase [(EryA3)(EryA2)(EryA1)]2|6-deoxyerythronolide B 6S-monooxygenase eryF|6-deoxyerythronolide B 6S-monooxygenase|6-deoxyerythronolide B synthase|3-L-mycarosyl erythronolide B desosaminyltransferase complex|dTDP-L-mycarosyl: erythronolide B mycarosyltransferase eryBV|3-L-mycarosyl erythronolide B desosaminyltransferase complex [(EryCII)(EryCIII)]2|dTDP-L-mycarosyl: erythronolide B mycarosyltransferase
|
erythronolide B|H2O|NADPH|dTDP-D-desosamine|dTDP-β-L-mycarose|(S)-methylmalonyl-CoA|NADP+|erythromycin D|3-α-mycarosylerythronolide B|6-deoxyerythronolide B|H+|propanoyl-CoA|CO2|oxygen|coenzyme A
|
15
|
|
L-arabinose degradation IV
|
PWY-7295
|
2-dehydro-3-deoxy-D-arabinonate aldolase [multifunctional]|aldose 1-dehydrogenase|2-dehydro-3-deoxy-D-arabinonate aldolase [multifunctional] [SSO224174]4|D-xylonate dehydratase|glycolaldehyde oxidoreductase|glycolaldehyde oxidoreductase [SSO2637][SSO2636][SSO2639]|L-arabinolactonase araB|malate synthase|glycolate dehydrogenase
|
2-dehydro-3-deoxy-L-arabinonate|H2O|NAD+|acetyl-CoA|glycolaldehyde|L-arabinofuranose|(S)-malate|H+|glyoxylate|L-arabinono-1,4-lactone|glycolate|L-arabinonate|L-arabinopyranose|pyruvate|NADH|coenzyme A
|
15
|
|
L-histidine degradation I
|
HISDEG-PWY
|
imidazolone-5-propionate hydrolase|formiminoglutamate formiminohydrolase [HutG]6|histidase|formiminoglutamate formiminohydrolase|urocanase
|
H2O|L-histidine|N-formimino-L-glutamate|urocanate|4-imidazolone-5-propanoate|L-glutamate|ammonium|formamide
|
15
|
|
phosphatidate metabolism, as a signaling molecule
|
PWY-7039
|
diacylglycerol kinase|phospholipase D|phosphoinositide phospholipase C 2|phosphoinositide phospholipase C 1|lipid phosphatidate phosphatase|phosphatidate kinase|phosphatidylinositol 4,5-bisphosphate lipase C [multifunctional]
|
H2O|a 1,2-diacyl-sn-glycerol 3-diphosphate|a 1,2-diacyl-sn-glycerol|H+|D-myo-inositol (1,4,5)-trisphosphate|choline|phosphate
|
15
|
|
spermidine biosynthesis III
|
PWY-6834
|
agmatine aminopropyltransferase|polyamine aminopropyltransferase|aminopropylagmatine ureohydrolase|pyruvoyl-dependent arginine decarboxylase
|
S-adenosyl-L-methionine|H2O|urea|L-arginine|S-methyl-5-thioadenosine|spermidine|H+|agmatine|N1-(3-aminopropyl)agmatine|CO2
|
15
|