|
superpathway of L-isoleucine biosynthesis I
|
PWY-3001
|
threonine deaminase|aspartate semialdehyde dehydrogenase|aspartate kinase III|aspartate aminotransferase, PLP-dependent|acetohydroxy acid isomeroreductase|branched-chain amino-acid aminotransferase|homoserine kinase|2-iminobutanoate/2-iminopropanoate deaminase [RidA]3|acetohydroxybutanoate synthase / acetolactate synthase|dihydroxy acid dehydratase|acetolactate synthase / acetohydroxybutanoate synthase|aspartate kinase / homoserine dehydrogenase|aspartate kinase II|threonine synthase
|
NADPH|(R)-2,3-dihydroxy-3-methylpentanoate|ammonium|(S)-3-methyl-2-oxopentanoate|H2O|NADP+|oxaloacetate|L-glutamate|L-homoserine|phosphate|pyruvate|CO2|L-aspartyl-4-phosphate|L-threonine|(2Z)-2-aminobut-2-enoate|L-isoleucine|2-iminobutanoate|(S)-2-aceto-2-hydroxybutanoate|L-aspartate-semialdehyde|L-aspartate|2-oxobutanoate|O-phospho-L-homoserine|H+|2-oxoglutarate
|
219
|
|
superpathway of anaerobic energy metabolism (invertebrates)
|
PWY-7389
|
methylmalonyl-CoA mutase|propionyl-CoA:succinate CoA transferase|pyruvate kinase|fumarate reductase complex [D78157][D78158][AB008568][D30650]|phosphoenolpyruvate carboxykinase|pyruvate dehydrogenase complex|NAD+-dependent malic enzyme, mitochondrial|succinyl-CoA:acetate CoA-transferase|alanine transaminase|fumarate reductase complex|propionyl-CoA carboxylase|fumarase|succinyl-CoA synthetase|alanine racemase|malate dehydrogenase|methylmalonyl-CoA epimerase|aspartate transaminase
|
fumarate|(S)-methylmalonyl-CoA|hydrogen carbonate|propanoate|H2O|NAD+|acetyl-CoA|propanoyl-CoA|oxaloacetate|L-alanine|ITP|L-glutamate|phosphate|pyruvate|CO2|acetate|phosphoenolpyruvate|(S)-malate|succinate|coenzyme A|(R)-methylmalonyl-CoA|IDP|L-aspartate|D-alanine|H+|succinyl-CoA|2-oxoglutarate|NADH
|
219
|
|
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
|
PWY0-166
|
dCTP deaminase|ribonucleoside-triphosphate reductase, subunit of anaerobic nucleoside-triphosphate reductase activating system|ribonucleoside-triphosphate reductase [NrdD]2|nucleoside diphosphate kinase|ribonucleoside diphosphate reductase 1|thymidylate synthase|thymidylate kinase|dTMP kinase|nucleoside triphosphate pyrophosphohydrolase|ribonucleoside-diphosphate reductase 2|deoxyuridine triphosphatase|pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase
|
H2O|diphosphate|H+|phosphate|ammonium|a 5,10-methylene-tetrahydrofolate|a 7,8-dihydrofolate
|
219
|
|
superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
|
PWY-6404
|
antigen 85C|decaprenylphospho-β-D-ribofuranose 2-dehydrogenase|DPPR synthase Rv3806c|fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase [GlmU]3|(Galf)30-Rha-GlcNAc-P-P-C50:decaprenyl-phosphoryl-β-D-arabinofuranose arabinofuranosyltransferase aftA|antigen 85A|arabinogalactan arabinosyl transferase embA|DPPR synthase|decaprenol-monophosphate-N-acetylglucosaminyltransferase rfe|Z-farnesyl diphosphate synthase Rv1086|arabinogalactan UDP-galactofuranosyltransferase 2 glfT2|Z-farnesyl diphosphate synthase|Z-decaprenyl diphosphate synthase uppS|(Galf)30-Rha-GlcNAc-P-P-C50:decaprenyl-phosphoryl-β-D-arabinofuranose arabinofuranosyltransferase|UDP-glucose 4-epimerase|decaprenyl-phosphoryl-2-keto-β-D-erythro-pentofuranose reductase|decaprenyl-N-acetyl-α-D-glucosaminyl-pyrophosphate:dTDP-α-L-rhamnose rhamnosyltransferase wbbL|decaprenyl-diphosphatase uppP|arabinogalactan α(1-->3) arabinofuranosyltransferase|Z-decaprenyl diphosphate synthase|decaprenyl-diphosphatase|antigen 85B|arabinogalactan UDP-galactofuranosyltransferase 2|arabinogalactan arabinosyl transferase embB|decaprenol-monophosphate-N-acetylglucosaminyltransferase|arabinogalactan galactofuranosyl transferase 1 glfT1|UDP-galactopyranose mutase|arabinogalactan α(1-->3) arabinofuranosyltransferase aftC|arabinogalactan galactofuranosyl transferase 1|arabinogalactan:decaprenyl-phosphoryl-β-D-arabinofuranose β(1-->2) arabinofuranosyltransferase|decaprenyl-N-acetyl-α-D-glucosaminyl-pyrophosphate:dTDP-α-L-rhamnose rhamnosyltransferase
|
FADH2|dTDP-4-dehydro-6-deoxy-α-D-glucopyranose|dTDP-α-D-glucose|dimethylallyl diphosphate|ω, mono-trans,octa-cis-decaprenyl diphosphate|L-glutamine|UDP-N-acetyl-α-D-glucosamine|(2Z,6E)-farnesyl diphosphate|α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol|dTDP-4-dehydro-β-L-rhamnose|D-glucosamine 6-phosphate|mycobacterial arabinogalactan primed with arabinofuran|NADPH|β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→6)14-β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)--L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol|H2O|NAD+|acetyl-CoA|β-D-fructofuranose 6-phosphate|β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol|NADP+|isopentenyl diphosphate|L-glutamate|mycobacterial arabinogalactan containing linear arabinofuran|phosphate|5-phospho-α-D-ribose 1-diphosphate|geranyl diphosphate|FAD|UDP-α-D-glucose|N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol|trans,octacis-decaprenylphospho-β-D-ribofuranose 5-phosphate|D-glucosamine 1-phosphate|dTDP-β-L-rhamnose|trans,octacis-decaprenylphospho-β-D-ribofuranose|mycolyl-arabinogalactan-peptidoglycan complex|mycobacterial arabinogalactan containing extended α(1->3) arabinofuran linkages|trans,octacis-decaprenylphospho-β-D-arabinofuranose|coenzyme A|N-acetyl-α-D-glucosamine 1-phosphate|mycobacterial arabinogalactan containing α(1->3) arabinofuran linkages|mycobacterial arabinogalactan containing α(1->3) and β(1->2) arabinofuran linkages|trans,octacis-decaprenyl phosphate|diphosphate|α-D-glucopyranose 1-phosphate|UDP-α-D-galactofuranose|α,α-trehalose|NADH|β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol|H+|D-glucopyranose 6-phosphate|UDP-α-D-galactose
|
218
|
|
Bifidobacterium shunt
|
P124-PWY
|
transaldolase [TalB]2|L-lactate dehydrogenase|glucose-6-phosphate isomerase|D-xylulose 5-phosphate phosphoketolase / D-fructose 6-phosphate phosphoketolase|xylulose-5-phosphate phosphoketolase / fructose-6-phosphate phosphoketolase
|
acetyl phosphate|D-ribulose 5-phosphate|acetate|NAD+|D-sedoheptulose 7-phosphate|3-phospho-D-glycerate|D-glucopyranose 6-phosphate|2-phospho-D-glycerate|H2O|phosphoenolpyruvate|β-D-fructofuranose 6-phosphate|D-xylulose 5-phosphate|D-glyceraldehyde 3-phosphate|H+|D-erythrose 4-phosphate|phosphate|1,3-bisphospho-D-glycerate|pyruvate|NADH|(S)-lactate
|
215
|
|
peptidoglycan biosynthesis III (mycobacteria)
|
PWY-6385
|
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-decaprenol N-acetylglucosamine transferase murG|phospho-N-acetylmuramoyl-pentapeptide-transferase|UDP-N-acetylmuramate--L-alanine ligase|peptidoglycan glycosyltransferase [multifunctional]|peptidoglycan glycosyltransferase [multifunctional] pon1|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase|UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-decaprenol N-acetylglucosamine transferase|UDP-N-acetylenolpyruvylglucosamine reductase|UDP-N-acetylglucosamine enolpyruvyl transferase|D-alanine--D-alanine ligase|UDP-N-acetylmuramoylalanine--D-glutamate ligase|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase|glutamate racemase|peptidoglycan transglycosylase/L,D transpeptidase|phospho-N-acetylmuramoyl-pentapeptide-transferase mraY
|
NADPH|ω, mono-trans,octa-cis-decaprenyl diphosphate|UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate|UDP-N-acetyl-α-D-glucosamine-enolpyruvate|a peptidoglycan with L,D cross-links (mycobacteria)|decaprenyl-pyrophosphoryl-(N-acetylglucosamine)-N-acetylmuramyl-(pentapeptide)|D-alanyl-D-alanine|H2O|UDP-N-acetyl-α-D-muramate|NADP+|L-alanine|L-glutamate|phosphate|UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine|a peptidoglycan with D,D cross-links (mycobacteria)|decaprenyl-diphospho-N-acetylmuramoyl-pentapeptide|meso-diaminopimelate|ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine|phosphoenolpyruvate|UDP-N-acetyl-α-D-muramoyl-L-alanine|di-trans,octa-cis-undecaprenyl diphosphate|D-glutamate|a peptidoglycan dimer (mycobacteria)|UDP-N-acetyl-α-D-glucosamine|trans,octacis-decaprenyl phosphate|D-alanine|H+
|
214
|
|
superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation
|
PWY-6604
|
butyryl-CoA dehydrogenase|NADH-dependent butanol dehydrogenase B|3-hydroxybutyryl-CoA dehydrogenase|alcohol/aldehyde dehydrogenase|phosphotransbutyrylase|NADH-dependent butanol dehydrogenase A|acetoacetate decarboxylase|pyruvate:ferredoxin oxidoreductase|acetate kinase|3-hydroxybutyryl-CoA dehydratase|butyrate--acetoacetate CoA-transferase|acetyl-CoA C-acetyltransferase|phosphotransacetylase|butyrate kinase|NADPH-dependent butanol dehydrogenas|phosphotransbutyrylase [Ptb]8|aldehyde/alcohol dehydrogenase|(S)-3-hydroxybutyryl-CoA dehydrogenase|butyrate kinase [Buk1]2
|
NADPH|acetyl phosphate|(S)-3-hydroxybutanoyl-CoA|butanoyl-CoA|crotonyl-CoA|H2O|NAD+|acetyl-CoA|butanoate|1-butanol|NADP+|acetaldehyde|acetoacetyl-CoA|phosphate|coenzyme A|1-butanal|CO2|ethanol|acetate|acetone|butanoyl phosphate|pyruvate|acetoacetate|H+|NADH
|
214
|
|
pyrimidine deoxyribonucleotides biosynthesis from CTP
|
PWY-7210
|
ectonucleoside triphosphate diphosphohydrolase 4|apyrase|nucleoside diphosphate kinase|thymidylate synthase|thymidylate kinase|ribonucleoside-diphosphate reductase|cancer-related nucleoside-triphosphatase|deoxycytidylate deaminase
|
H2O|H+|phosphate|ammonium|a 5,10-methylene-tetrahydrofolate|a 7,8-dihydrofolate
|
210
|
|
biotin biosynthesis I
|
BIOTIN-BIOSYNTHESIS-PWY
|
enoyl-[acyl-carrier-protein] reductase [FabI]4|3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [FabZ]6|KASI [FabB]2|7,8-diaminopelargonic acid synthase|3-oxoacyl-[acyl-carrier-protein] reductase|3-oxoacyl-[acyl-carrier-protein] reductase [FabG]4|8-amino-7-oxononanoate synthase|KASI|malonyl-[acp] methyltransferase bioC|pimeloyl-[acyl-carrier protein] methyl ester esterase|pimeloyl-[acp] methyl ester esterase|3-hydroxy-acyl-[acyl-carrier-protein] dehydratase|malonyl-[acp] methyltransferase|enoyl-[acyl-carrier-protein] reductase|dethiobiotin synthetase|biotin synthase
|
S-adenosyl-L-methionine|dethiobiotin|H2O|8-amino-7-oxononanoate|NADPH|phosphate|methanol|L-methionine|biotin|7,8-diaminopelargonate|NADP+|L-alanine|CO2|S-adenosyl-L-homocysteine|H+|NAD+|NADH|S-adenosyl-4-methylthio-2-oxobutanoate|5-deoxyadenosine
|
208
|
|
mycolate biosynthesis
|
PWYG-321
|
Rv3802c lipase/thioesterase|antigen 85C|methoxymycolic acid synthase 4|mycolyl-trehalose-6-phosphate phosphatase|methoxy mycolic acid synthase 3 mmaA3|meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II|methoxy mycolic acid synthase 2|methoxy mycolic acid synthase 3|meromycolic acid enoyl-[acyl-carrier-protein] reductase|methoxy mycolic acid synthase 1|Pks13|meromycolic acid 3-hydroxyacyl-[acyl-carrier-protein] dehydratase I [HadA][HadB]|lpqX|meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I|Rv2509 Rv2509|methoxy mycolic acid synthase 1 mmaA1|drugs-transport transmembrane ATP-binding protein ABC transporter Rv1273c|meromycolic acid 3-hydroxyacyl-[acyl-carrier-protein] dehydratase I|meromycolic acid 3-hydroxyacyl-[acyl-carrier-protein] dehydratase II|acyl-CoA synthetase|Pks13 pks13|meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I kasA|2-trans-enoyl-ACP isomerase|meromycolic acid 3-oxoacyl-[acyl-carrier-protein] reductase|Rv2509|meromycolic acid 3-hydroxyacyl-[acyl-carrier-protein] dehydratase II [HadB][HadC]|meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II kasB|antigen 85B|cyclopropane synthase|propionyl-CoA carboxylase beta chain 4|propionyl-coa carboxylase beta chain 5|cyclopropane mycolic acid synthase 2|methoxymycolic acid synthase 4 mmaA4|fatty acid synthase|fatty acid synthase fas|methoxy mycolic acid synthase 2 mmaA2|cyclopropane mycolic acid synthase 2 cmaA2|antigen 85A|meromycolic acid 3-oxoacyl-[acyl-carrier-protein] reductase [FabG1]2|acyl-CoA synthetase fadD32|trans-delta20-39-hydroxy-40-methyl-C60:1-[acp] oxidoreductase [multifunctional] Rv0161|trehalose-6-phosphate phosphatase OtsB1|trans-delta20-39-hydroxy-40-methyl-C60:1-[acp] oxidoreductase [multifunctional]|meromycolic acid enoyl-[acyl-carrier-protein] reductase [InhA]4
|
S-adenosyl-L-methionine|6-O-trans-methoxy-mycolyl-trehalose 6-phosphate|NADPH|2-carboxy-cerotoyl-CoA|a trans-keto-meroacyl-adenylate|6-O-mycolyl-trehalose 6-phosphate|NADP+|a cis-keto-meroacyl-adenylate|arabinogalactan-cis-methoxy-mycolate|α, α-trehalose 6,6-bismycolate|6-O-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol|α,α-trehalose 6-phosphate|H2O|NAD+|a cis-methoxy-meroacyl-adenylate|cerotoyl-CoA|a C52-α-meroacyl-adenylate|hydrogen carbonate|6-O-trans-methoxy-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol|trehalose-cis-keto-di-mycolate|6-O-cis-keto-mycolyl-trehalose 6-phosphate|6-O-trans-keto-mycolyl-trehalose 6-phosphate|a trans-methoxy-meroacyl-adenylate|phosphate|D-mannopyranosyl-1-phosphoheptaprenol|CO2|trehalose-trans-methoxy-di-mycolate|trehalose-trans-keto-di-mycolate|arabinogalactan-trans-methoxy-mycolate|6-O-cis-methoxy-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol|6-O-cis-methoxy-mycolyl-trehalose 6-phosphate|mycolyl-arabinogalactan-peptidoglycan complex|malonyl-CoA|trehalose-cis-keto-mono-mycolate|trehalose-trans-methoxy-mono-mycolate|coenzyme A|trehalose-cis-methoxy-di-mycolate|6-O-trans-keto-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol|trehalose-trans-keto-mono-mycolate|trehalose-cis-methoxy-mono-mycolate|diphosphate|6-O-cis-keto-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol|α,α-trehalose|S-adenosyl-L-homocysteine|arabinogalactan-cis-keto-mycolate|arabinogalactan-trans-keto-mycolate|H+|NADH
|
203
|