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superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis
|
PWY-7317
|
dTDP-4-dehydro-6-deoxy-D-glucose transaminase [WecE]4|dTDP-fucopyranose mutase fcf2|dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose:acetyl-CoA acetyltransferase qdtC|glucose-1-phosphate thymidylyltransferase|dTDP-4-dehydro-6-deoxyglucose reductase [NAD(P)H]|dTDP-glucose 4,6-dehydratase 2|dTDP-4-dehydrorhamnose reductase, subunit of dTDP-L-rhamnose synthetase|dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose:acetyl-CoA acetyltransferase|dTDP-glucose pyrophosphorylase|dTDP-4-amino-4,6-dideoxy-D-glucose transaminase|dTDP-6-deoxy-3,4-keto-hexulose isomerase|dTDP-glucose 4,6-dehydratase|dTDP-fucosamine acetyltransferase|dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose transaminase|dTDP-4-dehydro-6-deoxyglucose reductase [NAD(P)H] fcf1|dTDP-4-dehydro-6-deoxy-D-glucose transaminase|dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose transaminase|dTDP-4-dehydrorhamnose reductase|TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase|dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose 3-N-acetyltransferase|dTDP-4-dehydro-6-deoxyglucose reductase|dTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase|dTDP-4-dehydrorhamnose 3,5-epimerase, subunit of dTDP-L-rhamnose synthetase|dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)|dTDP-fucopyranose mutase|dTDP-fucosamine acetyltransferase rffC|dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) tll|bifunctional ketoisomerase / N-acetyltransferase FdtD|dTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase vioB|dTDP-4-keto-6-deoxyglucose 3,5-epimerase
|
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose|dTDP-α-D-glucose|dTDP-L-pneumose|NADPH|dTDP-α-D-fucopyranose|dTDP-thomosamine|H2O|NAD+|dTDP-N-acetylviosamine|acetyl-CoA|dTDP-3-acetamido-3,6-dideoxy-α-D-glucopyranose|NADP+|dTDP-3-dehydro-6-deoxy-α-D-galactopyranose|L-glutamate|dTDP-N-acetylthomosamine|dTDP-3-acetamido-α-D-fucose|dTDP-3-dehydro-6-deoxy-α-D-glucopyranose|dTDP-D-β-fucofuranose|dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose|dTDP-β-L-rhamnose|dTDP-viosamine|coenzyme A|diphosphate|α-D-glucopyranose 1-phosphate|dTDP-4-dehydro-β-L-rhamnose|dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose|H+|2-oxoglutarate|NADH
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28
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superpathway of methanogenesis
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PWY-6830
|
trimethylamine--corrinoid protein Co-methyltransferase [MttB]|phosphotransacetylase|formylmethanofuran:H4SPT formyltransferase|methylamine--corrinoid protein Co-methyltransferase|methyl-H4MPT:coenzyme M methyltransferase [(MtrA)(MtrB)(MtrC)(MtrD)(MtrE)(MtrF)(MtrG)(MtrH)]4|methylated [methylamine-specific corrinoid protein]:coenzyme M methyltransferase|methenyl-H4SPT cyclohydrolase|F420-dependent methylene-H4MPT reductase|methyl-H4SPT:CoM methyltransferase|acetyl-CoA decarbonylase/synthase complex β subunit|formylmethanofuran dehydrogenase|dimethylamine--corrinoid protein Co-methyltransferase [MtbB1]4|F420-dependent methylene-H4MPT reductase [Mer]4|formylmethanofuran:H4MPT formyltransferase|methyl-coenzyme M reductase|H2-forming methylene-H4MPT dehydrogenase|methyl-coenzyme M reductase II|methylated [methylamine-specific corrinoid protein]:coenzyme M methyltransferase mtbA|H2-forming methylene-H4MPT dehydrogenase [Hmd]4|methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase, subunit of MtaBC, methanol-CoM methyltransferase complex|methenyl-H4MPT cyclohydrolase|methylamine--corrinoid protein Co-methyltransferase [MtmB]3|dimethylamine--corrinoid protein Co-methyltransferase|acetyl-CoA decarbonylase/synthase complex γδ component|formylmethanofuran dehydrogenase, tungsten enzyme|methyl-CoM reductase|acetyl-CoA decarbonylase/synthase complex γδ component [CdhD1][CdhE1]|methyl-coenzyme M reductase I|acetate kinase|formylmethanofuran dehydrogenase, molybdenum enzyme|acetyl-CoA decarbonylase/synthase complex α2ε2 component|trimethylamine--corrinoid protein Co-methyltransferase|methyl-H4MPT:coenzyme M methyltransferase|MtaC protein: coenzyme M methyltransferase, subunit of methanol-CoM methyltransferase complex
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trimethylamine|tetrahydromethanopterin|methanol|methane|acetyl phosphate|5-formyl-tetrahydromethanopterin|coenzyme B|ammonium|H2O|a formyl-methanofuran|acetyl-CoA|N5-methyltetrahydromethanopterin|methyl-CoM|CoB-CoM heterodisulfide|methylamine|CO2|acetate|5-methyl-tetrahydrosarcinapterin|phosphate|5,10-methenyltetrahydromethanopterin|a reduced coenzyme F420|coenzyme A|carbon monoxide|tetrahydrosarcinapterin|H2|Na+|H+|5,10-methylene-tetrahydromethanopterin|coenzyme M|dimethylamine
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28
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superpathway of testosterone and androsterone degradation
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PWY-6937
|
3-ketosteroid 9α-hydroxylase reductase component|2-hydroxyhexa-2,4-dienoate hydratase|propanal dehydrogenase|5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA dehydrogenase|3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase|3α-hydroxysteroid dehydrogenase/carbonyl reductase|3-oxosteroid 1-dehydrogenase|4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase|3-keto-5α-steroid Δ4-dehydrogenase tesI|3β-hydroxysteroid dehydrogenase|4-hydroxy-2-oxohexanoate aldolase|3β-hydroxysteroid dehydrogenase [Hsd]4|3-keto-5α-steroid Δ4-dehydrogenase
|
(2Z,4Z)-2-hydroxyhexa-2,4-dienoate|NADPH|(2E)-3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-ylprop-2-enoyl-CoA|androsterone|FMNH2|3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione|5-hydroxy-3-(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-ylpropanoyl-CoA|3-(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-ylpropanoyl-CoA|3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl-3-oxopropanoyl-CoA|H2O|NAD+|acetyl-CoA|NADP+|3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl-3-hydroxypropanoyl-CoA|1-propanal|propanoyl-CoA|pyruvate|3-(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-ylpropanoate|3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxylate|androsta-1,4-diene-3,17-dione|androst-4-ene-3,17-dione|(S)-4-hydroxy-2-oxohexanoate|oxygen|coenzyme A|testosterone|3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione|diphosphate|(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1 (10),2-dien-4-oate|5α-androstane-3,17-dione|9α-hydroxyandrosta-1,4-diene-3,17-dione|H+|NADH
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28
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toluene degradation III (aerobic) (via p-cresol)
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PWY-5181
|
4-hydroxybenzyl alcohol dehydrogenase [multifunctional]|4-hydroxybenzoate hydroxylase|β-ketoadipate enol-lactone hydrolase [PcaD]3|toluene-4-monooxygenase|4-carboxymuconolactone decarboxylase [PcaC]6|β-ketoadipate:succinyl CoA transferase [PcaI]2[PcaJ]2|4-methylphenol methylhydroxylase|4-hydroxybenzaldehyde dehydrogenase
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3-oxoadipyl-CoA|2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate|NADPH|3-carboxy-cis,cis-muconate|4-hydroxybenzaldehyde|protocatechuate|3-oxoadipate|4-methylphenol|H2O|NAD+|acetyl-CoA|NADP+|4-hydroxybenzoate|CO2|3-oxoadipate enol lactone|4-hydroxybenzyl alcohol|succinate|oxygen|coenzyme A|H+|succinyl-CoA|toluene|NADH
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28
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(8E,10E)-dodeca-8,10-dienol biosynthesis
|
PWY-7654
|
long-chain-acyl-CoA dehydrogenase [ACADL]4
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lauroyl-CoA|NADPH|(9E)-dodecenoyl-CoA|(8E,10E)-dodeca-8,10-dienol|H2O|NAD+|acetyl-CoA|NADP+|(8E,10E)-dodeca-8,10-dienoyl-CoA|trans-hexadec-2-enoyl-CoA|(S)-3-hydroxyhexadecanoyl-CoA|(S)-3-hydroxytetradecanoyl-CoA|3-oxo-myristoyl-CoA|2-trans-tetradecenoyl-CoA|3-oxo-palmitoyl-CoA|oxygen|coenzyme A|myristoyl-CoA|palmitoyl-CoA|H+|(8E,10E)-dodeca-8,10-dienoate|NADH
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28
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benzoyl-CoA degradation I (aerobic)
|
PWY-1361
|
2,3-dehydroadipyl-CoA hydratase paaF|2,3-epoxybenzoyl-CoA dihydrolase [BoxC]2|3-hydroxyadipyl-CoA dehydrogenase (NAD+) paaH|benzoyl-CoA 2,3-epoxidase [(BoxA)2][BoxB]|2,3-epoxybenzoyl-CoA dihydrolase|3,4-dehydroadipyl-CoA semialdehyde dehydrogenase|benzoyl-CoA 2,3-epoxidase|3,4-dehydroadipyl-CoA semialdehyde dehydrogenase [BoxD]2
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3-oxoadipyl-CoA|trans-2,3-dehydroadipyl-coA|H2O|NAD+|acetyl-CoA|cis-3,4-dehydroadipyl-CoA semialdehyde|cis-3,4-dehydroadipyl-CoA|NADP+|benzoyl-CoA|(3S)-hydroxyadipyl-CoA|2,3-epoxy-2,3-dihydrobenzoyl-CoA|H+|succinyl-CoA|NADPH|formate|NADH|oxygen|coenzyme A
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28
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inosine-5'-phosphate biosynthesis III
|
PWY-7234
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inosine monophosphate cyclohydrolase|N5-carboxyaminoimidazole ribonucleotide mutase [PurE]8|N5-carboxyaminoimidazole ribonucleotide synthetase [PurK]2|adenylosuccinate lyase
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fumarate|H2O|N5-carboxyaminoimidazole ribonucleotide|5-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole|hydrogen carbonate|L-aspartate|H+|phosphate|formate
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27
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4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis (yeast)
|
PWY-7282
|
pyridoxine 4-dehydrogenase|HMP/HMP-P kinase and thiaminase II|hydroxymethylpyrimidine phosphate (HMP-P) kinase [multifunctional]|pyridoxal kinase / pyridoxamine kinase / pyridoxine kinase|phosphoribosylpyrophosphate amidotransferase|4-amino-2-methyl-5-phosphomethylpyrimidine synthase
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4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine|H2O|NADPH|L-glutamine|pyridoxine|NADP+|pyridoxal 5-phosphate|an HMP-P synthase-L-histidine|4-amino-2-methyl-5-(diphosphomethyl)pyrimidine|L-glutamate|pyridoxine 5-phosphate|hydrogen peroxide|H+|5-phospho-β-D-ribosylamine|2-hydroxypyridoxol|5-phospho-α-D-ribose 1-diphosphate|pyridoxal|diphosphate|oxygen
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27
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superpathway of polyamine biosynthesis I
|
POLYAMSYN-PWY
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lysine decarboxylase 2|agmatinase|spermidine synthase|ornithine decarboxylase, biosynthetic|adenosylmethionine decarboxylase|arginine decarboxylase, biosynthetic|lysine decarboxylase 1
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S-adenosyl-L-methionine|H2O|putrescine|aminopropylcadaverine|urea|cadaverine|L-ornithine|L-lysine|L-arginine|S-methyl-5-thioadenosine|spermidine|H+|agmatine|CO2
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27
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androstenedione degradation
|
PWY-6944
|
3-ketosteroid-Δ1-dehydrogenase|3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase|3-ketosteroid 9α-hydroxylase reductase component|3-ketosteroid 9α-hydroxylase complex|2-hydroxyhexa-2,4-dienoate hydratase|propanal dehydrogenase|5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA dehydrogenase|3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase|3-oxosteroid 1-dehydrogenase|4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase|3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-monooxygenase, subunit of 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase complex|4-hydroxy-2-oxohexanoate aldolase|3-ketosteroid 9α-hydroxylase
|
(2Z,4Z)-2-hydroxyhexa-2,4-dienoate|NADPH|(2E)-3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-ylprop-2-enoyl-CoA|FMNH2|3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione|5-hydroxy-3-(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-ylpropanoyl-CoA|3-(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-ylpropanoyl-CoA|3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl-3-oxopropanoyl-CoA|H2O|NAD+|acetyl-CoA|NADP+|3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl-3-hydroxypropanoyl-CoA|1-propanal|propanoyl-CoA|pyruvate|3-(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-ylpropanoate|3-(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxylate|androsta-1,4-diene-3,17-dione|androst-4-ene-3,17-dione|(S)-4-hydroxy-2-oxohexanoate|oxygen|coenzyme A|3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione|diphosphate|(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1 (10),2-dien-4-oate|9α-hydroxyandrosta-1,4-diene-3,17-dione|H+|NADH
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27
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