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ketogenesis
|
PWY66-367
|
mitochondrial D-β-hydroxybutyrate dehydrogenase|mitochondrial hydroxymethylglutaryl-CoA synthase|cytosolic acetyl-CoA acetyltransferase|hydroxymethylglutaryl-CoA synthase|acetoacetate decarboxylase|mitochondrial hydroxymethylglutaryl-CoA lyase|mitochondrial acetyl-CoA acetyltransferase
|
H2O|NAD+|acetyl-CoA|acetone|acetoacetate|acetoacetyl-CoA|CO2|H+|(R)-3-hydroxybutanoate|NADH|(S)-3-hydroxy-3-methylglutaryl-CoA|coenzyme A
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48
|
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sporopollenin precursors biosynthesis
|
PWY-6733
|
alcohol-forming fatty acyl-CoA reductase FAR2|fatty acyl-CoA synthetase|tetraketide α-pyrone reductase|tetraketide α-pyrone synthase A|alcohol-forming fatty acyl-CoA reductase|tetraketide α-pyrone synthase B|PHYLLO [multifunctional]|laurate 7-monooxygenase CYP703A2|laurate 7-monooxygenase|fatty acid ω-hydroxylase|lauroyl-CoA thioesterase [multifunctional]|long-chain fatty acid ω-hydroxylase
|
lauroyl-CoA|1,16-hexadecane-diol|NADPH|2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate|stearate|laurate|18-hydroxyoleate|18-hydroxystearate|2-(2,8-dihydroxytridecyl)-6-oxopyran-4-olate|H2O|palmitate|stearoyl-CoA|NADP+|18-hydroxystearoyl-CoA|CO2|(9Z)-octadec-9-ene-1,18-diol|H+|oleoyl-CoA|16-hydroxypalmitate|1,18-octadecane-diol|malonyl-CoA|oxygen|coenzyme A|dodecane-1,7-diol|7-hydroxylauroyl-CoA|palmitoyl-CoA|diphosphate|16-hydroxypalmitoyl-CoA|oleate|7-hydroxylaurate|18-hydroxyoleoyl-CoA
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48
|
|
cholesterol degradation to androstenedione II (cholesterol dehydrogenase)
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PWY-6946
|
α-methylacyl-CoA racemase mcr|cholest-4-en-3-one C26 monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]|3-oxocholest-4,24-dien-26-oyl-CoA hydratase echA19|3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase|3-oxochol-4-en-24-oyl-CoA dehydrogenase|3-oxocholest-4-en-26-oate--CoA ligase fadD19|steroid 3-ketoacyl-CoA thiolase|3-oxocholest-4-en-26-oate--CoA ligase|3-oxocholest-4-en-26-oyl-CoA dehydrogenase [ChsE5]2[ChsE4]2|3 β-hydroxysteroid dehydrogenase hsdD|cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]|3-oxocholest-4,24-dien-26-oyl-CoA hydratase|3-oxo-23,24-bisnorchol-4,17(20)-dien-22-oyl-CoA hydratase|3 β-hydroxysteroid dehydrogenase|cholesterol oxidase|3-oxo-23,24-bisnorchol-4-en-17-ol-22-oyl-CoA lyase|3-oxocholest-4-en-26-oyl-CoA dehydrogenase|steroid 3-ketoacyl-CoA thiolase [FadA5]2|3-oxochol-4-en-24-oyl-CoA dehydrogenase [ChsE3]2|α-methylacyl-CoA racemase|cholest-4-en-3-one C26 monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] cyp142
|
(25S)-3-oxocholest-4-en-26-oyl-CoA|(25R)-26-oxocholest-4-en-3-one|24-hydroxy-3-oxocholest-4-en-26-oyl-CoA|cholest-4-en-3-one|3-oxo-4-pregnene-20-carboxyl-CoA|cholest-5-en-3-one|22-hydroxy-3-oxochol-4-en-24-oyl-CoA|3,24-dioxocholest-4-en-26-oyl-CoA|H2O|NAD+|acetyl-CoA|(25S)-3-oxocholest-4-en-26-oate|cholesterol|17-hydroxy-3-oxo-4-pregnane-20-carboxyl-CoA|3-oxochol-4,22-dien-24-oyl-CoA|propanoyl-CoA|3,22-dioxochol-4-en-24-oyl-CoA|(25R)-26-hydroxycholest-4-en-3-one|(25S)-26-oxocholest-4-en-3-one|(25R)-3-oxocholest-4-en-26-oate|androst-4-ene-3,17-dione|3-oxocholest-4,24-dien-26-oyl-CoA|oxygen|coenzyme A|(25R)-3-oxocholest-4-en-26-oyl-CoA|(25S)-26-hydroxycholest-4-en-3-one|3-oxo-4,17-pregnadiene-20-carboxyl-CoA|diphosphate|H+|3-oxochol-4-en-24-oyl-CoA|NADH
|
48
|
|
pantothenate and coenzyme A biosynthesis I
|
PANTOSYN-PWY
|
pantothenate synthetase|phosphopantetheine adenylyltransferase|2-dehydropantoate 2-reductase|pantothenate kinase|acetohydroxy acid isomeroreductase|aspartate 1-decarboxylase|3-methyl-2-oxobutanoate hydroxymethyltransferase|dephospho-CoA kinase
|
L-cysteine|H2O|4-phosphopantetheine|NADPH|2-dehydropantoate|3-methyl-2-oxobutanoate|a tetrahydrofolate|diphosphate|(R)-4-phosphopantothenate|NADP+|R-4-phosphopantothenoyl-L-cysteine|L-aspartate|a 5,10-methylene-tetrahydrofolate|(R)-pantoate|H+|3-dephospho-CoA|(R)-pantothenate|CO2|β-alanine|coenzyme A
|
47
|
|
S-adenosyl-L-methionine cycle I
|
PWY-6151
|
S-ribosylhomocysteine lyase|S-adenosylmethionine synthetase|cobalamin-independent homocysteine transmethylase
|
S-adenosyl-L-methionine|L-methionine|H2O|N5-methyl--tetrahydropteroyl tri-L-glutamate|S-ribosyl-L-homocysteine|adenine|diphosphate|L-homocysteine|autoinducer 2|tetrahydropteroyl tri-L-glutamate|H+|phosphate|S-adenosyl-L-homocysteine
|
47
|
|
superpathway of demethylmenaquinol-8 biosynthesis
|
PWY-5861
|
1,4-dihydroxy-2-naphthoate octaprenyltransferase|o-succinylbenzoate synthase|2-succinylbenzoate--CoA ligase|(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase|1,4-dihydroxy-2-naphthoyl-CoA thioesterase|isochorismate synthase 2|1,4-dihydroxy-2-naphthoyl-CoA synthase|2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase|o-succinylbenzoate-CoA ligase|octaprenyl diphosphate synthase|1,4-dihydroxy-2-naphthoate octaprenyltransferase menA
|
2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate|2-oxoglutarate|H2O|demethylmenaquinol-8|4-(2-carboxyphenyl)-4-oxobutyryl-CoA|2-carboxy-1,4-naphthoquinol|isochorismate|diphosphate|1,4-dihydroxy-2-naphthoyl-CoA|isopentenyl diphosphate|chorismate|(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate|all-trans-octaprenyl diphosphate|2-succinylbenzoate|H+|pyruvate|CO2|(2E,6E)-farnesyl diphosphate|coenzyme A
|
47
|
|
icosapentaenoate biosynthesis II (6-desaturase, mammals)
|
PWY-7049
|
acyl-CoA 4/6/8-desaturase, subunit of acyl-CoA 6-desaturase complex|long-chain-fatty-acid--CoA ligase 1|polyunsaturated long-chain fatty acid elongase 5|acyl-CoA 5-desaturase FADS1|acyl-CoA 5-desaturase
|
(8Z,11Z,14Z,17Z)-3-hydroxy-icosa-8,11,14,17-tetraenoyl-CoA|H2O|icosapentaenoyl-CoA|diphosphate|α-linolenoyl-CoA|α-linolenate|(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA|(2E,8Z,11Z,14Z,17Z)-icosa-2,8,11,14,17-pentaenoyl-CoA|stearidonoyl-CoA|3-oxo-icosatetraenoyl-CoA|H+|malonyl-CoA|CO2|oxygen|coenzyme A
|
47
|
|
cholesterol degradation to androstenedione I (cholesterol oxidase)
|
PWY-6945
|
3-oxocholest-4,24-dien-26-oyl-CoA hydratase echA19|3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase|3-oxochol-4-en-24-oyl-CoA dehydrogenase|steroid 3-ketoacyl-CoA thiolase|3-oxocholest-4-en-26-oate--CoA ligase|3-oxocholest-4-en-26-oyl-CoA dehydrogenase [ChsE5]2[ChsE4]2|3-oxocholest-4-en-26-oate–CoA ligase|cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]|3-oxocholest-4,24-dien-26-oyl-CoA hydratase|3-oxo-23,24-bisnorchol-4,17(20)-dien-22-oyl-CoA hydratase|3 β-hydroxysteroid dehydrogenase|cholesterol oxidase|3-oxo-23,24-bisnorchol-4-en-17-ol-22-oyl-CoA lyase|3-oxocholest-4-en-26-oyl-CoA dehydrogenase|steroid 3-ketoacyl-CoA thiolase [FadA5]2|3-oxochol-4-en-24-oyl-CoA dehydrogenase [ChsE3]2
|
(25S)-3-oxocholest-4-en-26-oyl-CoA|24-hydroxy-3-oxocholest-4-en-26-oyl-CoA|cholest-4-en-3-one|3-oxo-4-pregnene-20-carboxyl-CoA|cholest-5-en-3-one|22-hydroxy-3-oxochol-4-en-24-oyl-CoA|3,24-dioxocholest-4-en-26-oyl-CoA|H2O|NAD+|acetyl-CoA|(25S)-3-oxocholest-4-en-26-oate|cholesterol|17-hydroxy-3-oxo-4-pregnane-20-carboxyl-CoA|3-oxochol-4,22-dien-24-oyl-CoA|propanoyl-CoA|3,22-dioxochol-4-en-24-oyl-CoA|(25S)-26-oxocholest-4-en-3-one|hydrogen peroxide|androst-4-ene-3,17-dione|3-oxocholest-4,24-dien-26-oyl-CoA|oxygen|coenzyme A|(25S)-26-hydroxycholest-4-en-3-one|3-oxo-4,17-pregnadiene-20-carboxyl-CoA|diphosphate|H+|3-oxochol-4-en-24-oyl-CoA|NADH
|
47
|
|
superpathway of cholesterol biosynthesis
|
PWY66-5
|
lamin B receptor LBR|3-keto-steroid reductase|diphosphomevalonate decarboxylase|NAD(P)-dependent 3β-hydroxy-4α-carboxy-sterol 3-dehydrogenase (decarboxylating) NSDHL|24-dehydrocholesterol reductase precursor|geranylgeranyl diphosphate synthase|mitochondrial acetyl-CoA acetyltransferase|isopentenyl-diphosphate delta-isomerase 2|phosphomevalonate kinase|3-keto-steroid reductase HSD17B7|cytochrome P450 51A1|3-hydroxy-3-methylglutaryl-coenzyme A reductase|farnesyl-diphosphate farnesyltransferase|24-dehydrocholesterol reductase precursor DHCR24|C-4 methyl sterol oxidase SC4MOL|squalene monooxygenase|3-β-hydroxysteroid-Δ8-Δ7-isomerase [EBP]4|cytochrome P450 51A1 CYP51A1|Δ 7-sterol reductase DHCR7|E-farnesyl diphosphate synthase|isopentenyl-diphosphate delta-isomerase 1|C-4 methyl sterol oxidase|hydroxymethylglutaryl-CoA synthase|mevalonate kinase|Δ 7-sterol reductase|lanosterol synthase|3-β-hydroxysteroid-Δ8-Δ7-isomerase|lamin B receptor|mitochondrial hydroxymethylglutaryl-CoA synthase|lathosterol oxidase SC5DL|cytosolic acetyl-CoA acetyltransferase|NAD(P)-dependent 3β-hydroxy-4α-carboxy-sterol 3-dehydrogenase (decarboxylating)|lathosterol oxidase
|
14-hydroxylanosterol|NADPH|4α-carboxy-5α-cholesta-8,24-dien-3β-ol|dimethylallyl diphosphate|zymosterol|4,4-dimethyl-cholesta-8,12,24-trienol|geranyl diphosphate|lathosterol|cholesterol|4,4-dimethylzymosterol|4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol|24,25-dihydrolanosterol|4,4-dimethyl-14α-formyl-5α-cholesta-8-en-3β-ol|H2O|5α-cholesta-8,24-dien-3-one|(3S)-2,3-epoxy-2,3-dihydrosqualene|acetyl-CoA|(S)-3-hydroxy-3-methylglutaryl-CoA|NADP+|4α-carboxy-5α-cholesta-8-en-3β-ol|isopentenyl diphosphate|4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol|(R)-mevalonate diphosphate|acetoacetyl-CoA|4α-methyl-zymosterol|phosphate|formate|CO2|4α-carboxy-4β-methyl-5α-cholesta-8-en-3β-ol|4α-hydroxymethyl-5α-cholesta-8-en-3β-ol|4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol|4α-formyl-5α-cholesta-8-en-3β-ol|(R)-mevalonate 5-phosphate|4,4-dimethyl-14α-hydroxymethyl-5α-cholesta-8-en-3β-ol|5α-cholesta-8-en-3-one|3-dehydro-4-methylzymosterol|(R)-mevalonate|4α-methyl-5α-cholesta-8-en-3-one|oxygen|coenzyme A|4α-hydroxymethyl-4β-methyl-5α-cholesta-8-en-3β-ol|4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol|7-dehydrodesmosterol|4α-methyl-cholesta-8-enol|diphosphate|14-oxolanosterol|squalene|5α-cholesta-7,24-dien-3β-ol|4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol|4α-formyl-5α-cholesta-8,24-dien-3β-ol|4,4-dimethyl-5α-cholesta-8-en-3-β-ol|lanosterol|desmosterol|H+|4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol|zymostenol|7-dehydrocholesterol|(2E,6E)-farnesyl diphosphate
|
47
|
|
superpathway of demethylmenaquinol-6 biosynthesis I
|
PWY-5860
|
|
2-oxoglutarate|H2O|2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate|4-(2-carboxyphenyl)-4-oxobutyryl-CoA|2-carboxy-1,4-naphthoquinol|isochorismate|diphosphate|(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate|1,4-dihydroxy-2-naphthoyl-CoA|isopentenyl diphosphate|chorismate|demethylmenaquinol-6|2-succinylbenzoate|H+|all-trans-hexaprenyl diphosphate|pyruvate|CO2|(2E,6E)-farnesyl diphosphate|coenzyme A
|
46
|