|
thymine degradation
|
PWY-6430
|
(NADP)-dependent dihydropyrimidine dehydrogenase|dihydropyrimidine dehydrogenase|dihydropyrimidinase|3-amino-isobutyrate synthase / β-alanine synthase|β-ureidopropionase
|
H2O|NADPH|5,6-dihydrothymine|NADP+|CO2|(R)-3-ureido-isobutanoate|H+|(R)-3-amino-2-methylpropanoate|ammonium|thymine
|
0
|
|
thyroid hormone biosynthesis
|
PWY-6241
|
cathepsin L|thyroid peroxidase TPO|thyroid peroxidase|cathepsin B|cathepsin D|cathepsin K
|
H2O|3,5,3-triiodo-L-thyronine|iodide|H+|thyroglobulin-L-tyrosine|thyroglobulin-3-iodotyrosine|unspecified degradation products|hydrogen peroxide|thyroglobulin-3,5-diiodotyrosine|thyroglobulin-aminoacrylate
|
0
|
|
thyroid hormone metabolism I (via deiodination)
|
PWY-6260
|
type I iodothyronine deiodinase
|
3-monoiodothyronine|3,5,3-triiodo-L-thyronine|iodide|3-monoiodothyronine|3,3,5-triiodo-L-thyronine|3,5-diiodothyronine|L-thyronine|H+|3,3-diiodothyronine|3,5-diiodothyronine
|
0
|
|
thyroid hormone metabolism II (via conjugation and/or degradation)
|
PWY-6261
|
triiodothyroacetate phenol UDP-glucuronosyltransferase|UDP-glucuronosyltransferase 1A3|triiodothyroacetate acyl UDP-glucuronosyltransferase|tetraiodothyroacetate acyl UDP-glucuronosyltransferase|sulfotransferase 1A2|UDP-glucuronosyltransferase 1-8|UDP-glucuronosyltransferase 1A3 UGT1A3|tetraiodothyroacetate phenol UDP-glucuronosyltransferase|sulfotransferase 1A1
|
tetraiodothyroacetate ether glucuronide|L-thyroxine acyl β-D-glucuronide|3,5,3-triiodo-L-thyronine|iodide|tetraiodothyroacetate ester glucuronide|3,5,3-triiodo-L-thyronine acyl β-D-glucuronide|3-phosphoadenylyl-sulfate|adenosine 3,5-bisphosphate|L-thyroxine phenolic β-D-glucuronide|thyronamine|triiodothyroacetate ester glucuronide|UDP-α-D-glucuronate|H+|3,5,3-triiodo-L-thyronine phenolic β-D-glucuronide|triiodothyroacetate ether glucuronide|3,3,5-triiodothyroacetate|tetraiodothyroacetate|3-iodothyronamine|thyroxine sulfate
|
0
|
|
thyronamine and iodothyronamine metabolism
|
PWY-6688
|
type I iodothyronine deiodinase
|
3,3,5,5-tetraiodothyronamine|3,3,5-triiodothyronamine|3-iodothyronamine|iodide|3,5-diiodothyronamine|thyronamine|H+|3,3-diiodothyronamine|3,3,5-triiodothyronamine|3-iodothyronamine|3,5-diiodothyronamine
|
0
|
|
toluene degradation to 2-oxopent-4-enoate (via 4-methylcatechol)
|
TOLUENE-DEG-3-OH-PWY
|
toluene 3-monooxygenase [(TbuA1)2(TbuA2)2(TbuU)2][TbuC][TbuV][TbuB]|toluene 3-monooxygenase|2-hydroxymuconate semialdehyde hydrolase
|
acetate|NAD+|2-oxopent-4-enoate|H2O|H+|toluene|4-methylphenol|cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate|NADH|oxygen|4-methylcatechol
|
0
|
|
toluene degradation to 2-oxopent-4-enoate (via toluene-cis-diol)
|
TOLUENE-DEG-DIOL-PWY
|
cis-toluene dihydrodiol dehydrogenase todD|2-hydroxy-6-oxohepta-2,4-dienoate hydrolase|toluene 1,2-dioxygenase [(TodC1)2(TodC2)2][TodA][TodB]|3-methylcatechol 2,3-dioxygenase|toluene 1,2-dioxygenase|cis-toluene dihydrodiol dehydrogenase
|
acetate|NAD+|3-methylcatechol|H2O|2-oxopent-4-enoate|H+|(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol|toluene|cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate|NADH|oxygen
|
0
|
|
toluene degradation to 2-oxopent-4-enoate I (via o-cresol)
|
TOLUENE-DEG-2-OH-PWY
|
toluene ortho-monooxygenase [(TomA3)2(TomA1)2(TomA4)2][TomA5][TomA2]|catechol 2,3-dioxygenase|2-hydroxy-6-oxohepta-2,4-dienoate hydrolase|toluene ortho-monooxygenase
|
acetate|NAD+|3-methylcatechol|H2O|2-oxopent-4-enoate|H+|toluene|cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate|2-methylphenol|NADH|oxygen
|
0
|
|
toluene degradation to 4-methylphenol
|
TOLUENE-DEG-4-OH-PWY
|
toluene-4-monooxygenase
|
H2O|NAD+|H+|toluene|4-methylphenol|NADH|oxygen
|
0
|
|
toluene degradation to benzoate
|
TOLUENE-DEG-CATECHOL-PWY
|
benzyl alcohol dehydrogenase|benzaldehyde dehydrogenase|benzyl alcohol dehydrogenase [XylB]2|xylene monooxygenase|benzaldehyde dehydrogenase [multifunctional]|toluene monooxygenase / 4-nitrotoluene monooxygenase
|
benzyl alcohol|H2O|benzaldehyde|NAD+|benzoate|H+|toluene|NADH|oxygen
|
0
|