D-fructuronate degradation
|
PWY-7242
|
multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase|2-keto-3-deoxygluconokinase|D-mannonate oxidoreductase|D-mannonate dehydrogenase|2-keto-3-deoxygluconate kinase|4-hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxy-phosphogluconate aldolase|D-mannonate dehydratase
|
D-mannonate|H2O|NAD+|D-fructuronate|D-glyceraldehyde 3-phosphate|2-dehydro-3-deoxy-D-gluconate 6-phosphate|2-dehydro-3-deoxy-D-gluconate|H+|pyruvate|NADH
|
73
|
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP)
|
PWY-5121
|
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase ispG|1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase|isopentenyl pyrophosphate isomerase|2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase|4-diphosphocytidyl-2C-methyl-D-erythritol synthase|1-deoxy-D-xylulose 5-phosphate reductoisomerase|1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase|4-diphosphocytidyl-2-C-methylerythritol kinase|geranylpyrophosphate synthase|1-deoxy-D-xylulose 5-phosphate synthase|ω,E,E-farnesyl diphosphate synthase / dimethylallyltranstransferase|isopentenyl diphosphate isomerase|geranyl diphosphate synthase / farnesyl diphosphate synthase|ω,E,E-farnesyl diphosphate synthase|1-deoxyxylulose-5-phosphate synthase|geranylgeranyl pyrophosphate synthase|farnesyl diphosphate synthase
|
1-deoxy-D-xylulose 5-phosphate|H2O|NADPH|dimethylallyl diphosphate|(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate|diphosphate|D-glyceraldehyde 3-phosphate|NADP+|isopentenyl diphosphate|geranylgeranyl diphosphate|2-C-methyl-D-erythritol-2,4-cyclodiphosphate|2-C-methyl-D-erythritol 4-phosphate|geranyl diphosphate|H+|4-(cytidine 5-diphospho)-2-C-methyl-D-erythritol|pyruvate|CO2|(2E,6E)-farnesyl diphosphate|2-phospho-4-(cytidine 5-diphospho)-2-C-methyl-D-erythritol
|
72
|
taxadiene biosynthesis (engineered)
|
PWY-7392
|
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase ispG|1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase|2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase|geranylgeranyl diphosphate synthase|1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase|4-diphosphocytidyl-2-C-methylerythritol kinase|taxadiene synthase|1-deoxy-D-xylulose 5-phosphate reductoisomerase|isopentenyl diphosphate isomerase|geranyl diphosphate synthase / farnesyl diphosphate synthase|1-deoxyxylulose-5-phosphate synthase|4-diphosphocytidyl-2C-methyl-D-erythritol synthase
|
1-deoxy-D-xylulose 5-phosphate|H2O|NADPH|dimethylallyl diphosphate|(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate|diphosphate|D-glyceraldehyde 3-phosphate|NADP+|isopentenyl diphosphate|geranylgeranyl diphosphate|taxa-4,11-diene|2-C-methyl-D-erythritol-2,4-cyclodiphosphate|2-C-methyl-D-erythritol 4-phosphate|geranyl diphosphate|H+|4-(cytidine 5-diphospho)-2-C-methyl-D-erythritol|pyruvate|CO2|(2E,6E)-farnesyl diphosphate|2-phospho-4-(cytidine 5-diphospho)-2-C-methyl-D-erythritol
|
72
|
L-histidine biosynthesis
|
HISTSYN-PWY
|
imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase|ATP phosphoribosyltransferase|imidazoleglycerol phosphate synthase|imidazoleglycerolphosphate dehydratase|phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase|phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase|histidinol dehydrogenase|histidinol-phosphate phosphatase [multifunctional]|histidinal dehydrogenase / histidinol dehydrogenase|imidazoleglycerolphosphate synthase|imidazoleglycerol phosphate dehydratase|histidinol phosphate phosphatase|histidinol phosphate aminotransferase|ATP PPRTase|ATP-phosphoribosyl transferase|ATP-phosphoribosyl transferase|imidazole glycerol phosphate synthase|phosphoribosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide isomerase|histidinol-phosphate aminotransferase
|
1-(5-phospho-β-D-ribosyl)-ATP|histidinal|H2O|NAD+|histidinol|L-histidine|L-glutamine|diphosphate|L-histidinol-phosphate|D-erythro-imidazole-glycerol-phosphate|L-glutamate|imidazole acetol-phosphate|H+|phosphate|5-phospho-α-D-ribose 1-diphosphate|2-oxoglutarate|NADH
|
72
|
adenosine deoxyribonucleotides de novo biosynthesis II
|
PWY-7220
|
nucleoside diphosphate kinase|ribonucleoside diphosphate reductase 1|ribonucleoside-triphosphate reductase, subunit of anaerobic nucleoside-triphosphate reductase activating system|ribonucleoside-triphosphate reductase [NrdD]2|ribonucleoside-diphosphate reductase 2
|
H2O
|
72
|
guanosine deoxyribonucleotides de novo biosynthesis II
|
PWY-7222
|
nucleoside diphosphate kinase|ribonucleoside diphosphate reductase 1|ribonucleoside-triphosphate reductase, subunit of anaerobic nucleoside-triphosphate reductase activating system|ribonucleoside-triphosphate reductase [NrdD]2|ribonucleoside-diphosphate reductase 2
|
H2O
|
72
|
isoprene biosynthesis II (engineered)
|
PWY-7391
|
isoprene synthase IspS|acetyl-CoA acetyltransferase/HMG-CoA reductase|IPP isomerase|mevalonate diphosphate decarboxylase|hydroxymethylglutaryl-CoA synthase|mevalonate kinase|isoprene synthase|phosphomevalonate kinase
|
H2O|NADPH|dimethylallyl diphosphate|acetyl-CoA|isoprene|diphosphate|acetoacetyl-CoA|NADP+|isopentenyl diphosphate|(R)-mevalonate diphosphate|H+|(R)-mevalonate 5-phosphate|phosphate|(R)-mevalonate|CO2|(S)-3-hydroxy-3-methylglutaryl-CoA|coenzyme A
|
71
|
mevalonate pathway I
|
PWY-922
|
hydroxymethylglutaryl CoA synthase|HMG-CoA reductase 2|diphosphomevalonate decarboxylase|isopentenyl-diphosphate delta-isomerase 1|mitochondrial hydroxymethylglutaryl-CoA synthase|mevalonate diphosphate decarboxylase|isopentenyl-diphosphate delta-isomerase 2|hydroxymethylglutaryl-CoA synthase|3-hydroxy-3-methylglutaryl coenzyme A reductase|acetoacetyl-CoA thiolase|isopentenyl diphosphate isomerase|IPP isomerase|cytosolic acetyl-CoA acetyltransferase|acetyl-CoA C-acetyltransferase|mitochondrial acetyl-CoA acetyltransferase|mevalonate kinase|HMG-CoA reductase 1|phosphomevalonate kinase|3-hydroxy-3-methylglutaryl-coenzyme A reductase
|
H2O|NADPH|dimethylallyl diphosphate|acetyl-CoA|(R)-mevalonate 5-phosphate|acetoacetyl-CoA|NADP+|isopentenyl diphosphate|(R)-mevalonate diphosphate|H+|phosphate|(R)-mevalonate|CO2|(S)-3-hydroxy-3-methylglutaryl-CoA|coenzyme A
|
71
|
TCA cycle VII (acetate-producers)
|
PWY-7254
|
succinate dehydrogenase sdhA|malate:quinone oxidoreductase mqo|succinyl-CoA:acetate CoA-transferase|citrate synthase
|
fumarate|acetate|NADPH|acetyl-CoA|2-oxoglutarate|NADP+|(S)-malate|citrate|H2O|CO2|oxaloacetate|D-threo-isocitrate|H+|succinyl-CoA|NAD+|cis-aconitate|succinate|NADH|coenzyme A
|
71
|
aerobic respiration II (cytochrome c) (yeast)
|
PWY-7279
|
ubiquinol-cytochrome C oxidoreductase|succinate dehydrogenase (ubiquinone)|NADH:ubiquinone oxidoreductase (internal)|NADH:ubiquinone oxidoreductase 2 (external)|NADH:ubiquinone oxidoreductase 1 (external)
|
fumarate|H2O|NAD+|H+|succinate|NADH|oxygen
|
70
|