|
superpathway of phospholipid biosynthesis I (bacteria)
|
PHOSLIPSYN-PWY
|
phosphatidylserine synthase|1-acylglycerol-3-phosphate O-acyltransferase|CDP-diglyceride synthetase|cardiolipin synthase 3|cardiolipin synthase 2|glycerol-3-phosphate dehydrogenase, biosynthetic|cardiolipin synthase 1|phosphatidylglycerophosphate synthase|phosphatidylserine decarboxylase|glycerol-3-phosphate acyltransferase|phosphatidylglycerophosphatase [multifunctional]|phosphatidylglycerophosphatase C|phosphatidylglycerophosphatase A
|
H2O|L-serine|a CDP-diacylglycerol|ethanolamine|diphosphate|an L-1-phosphatidylserine|a 1-acyl-sn-glycerol 3-phosphate|glycerone phosphate|a cardiolipin|1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate|H+|sn-glycerol 3-phosphate|phosphate|glycerol|CO2|coenzyme A
|
102
|
|
superpathway of ergosterol biosynthesis I
|
ERGOSTEROL-SYN-PWY
|
HMG-CoA reductase 2|C-14 sterol reductase|cytochrome P450 51|C-5 sterol desaturase|mevalonate diphosphate decarboxylase|C-24 sterol reductase|phosphomevalonate kinase|HMG-CoA reductase 1|sterol C-22 desaturase|C-8 sterol isomerase|SAM:C-24 sterol methyltransferase [ERG6]4|2,3-oxidosqualene-lanosterol cyclase|acetyl-CoA C-acetyltransferase|squalene monooxygenase|hydroxymethylglutaryl-CoA synthase|mevalonate kinase|farnesyl diphosphate synthase|C-24 sterol reductase ERG4|squalene synthetase|3-keto sterol reductase, subunit of sterol C-4 demethylation complex|sterol C-22 desaturase ERG5|IPP isomerase|SAM:C-24 sterol methyltransferase|C-4 methyl sterol oxidase, subunit of sterol C-4 demethylation complex|C-3 sterol dehydrogenase, subunit of sterol C-4 demethylation complex
|
S-adenosyl-L-methionine|NADPH|4α-carboxy-5α-cholesta-8,24-dien-3β-ol|dimethylallyl diphosphate|zymosterol|ergosta-5,7,24(28)-trien-3β-ol|geranyl diphosphate|4,4-dimethylzymosterol|4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol|4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol|H2O|5α-cholesta-8,24-dien-3-one|(3S)-2,3-epoxy-2,3-dihydrosqualene|acetyl-CoA|(S)-3-hydroxy-3-methylglutaryl-CoA|NADP+|isopentenyl diphosphate|(R)-mevalonate diphosphate|acetoacetyl-CoA|4α-methyl-zymosterol|phosphate|fecosterol|formate|CO2|4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol|episterol|(R)-mevalonate 5-phosphate|ergosta-5,7,22,24(28)-tetraen-3-β-ol|ergosterol|4,4-dimethyl-cholesta-8,12,24-trienol|3-dehydro-4-methylzymosterol|(R)-mevalonate|oxygen|coenzyme A|diphosphate|squalene|S-adenosyl-L-homocysteine|4α-formyl-5α-cholesta-8,24-dien-3β-ol|lanosterol|H+|4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol|(2E,6E)-farnesyl diphosphate
|
102
|
|
L-glutamate degradation V (via hydroxyglutarate)
|
P162-PWY
|
2-hydroxyglutaryl-CoA dehydratase [HgdA][HgdB]|acetate-CoA ligase (ADP-forming) [AcdA]2[AcdB]2|glutaconyl-CoA decarboxylase|acetyl-CoA C-acetyltransferase|2-oxoglutarate reductase|glutaconate CoA-transferase|2-hydroxyglutaryl-CoA dehydratase|glutaconate CoA-transferase [GctA]4[GctB]4|glutamate dehydrogenase (NAD-dependent)
|
(S)-3-hydroxybutanoyl-CoA|(E)-glutaconyl-CoA|acetate|NAD+|acetyl-CoA|butanoate|2-oxoglutarate|acetoacetyl-CoA|H2O|CO2|(R)-2-hydroxyglutaryl-CoA|ammonium|(R)-2-hydroxyglutarate|L-glutamate|H+|phosphate|butanoyl-CoA|NADH|crotonyl-CoA|coenzyme A
|
100
|
|
superpathway of hexuronide and hexuronate degradation
|
GALACT-GLUCUROCAT-PWY
|
altronate oxidoreductase uxaB|altronate oxidoreductase|β-D-glucuronidase [UidA]4|D-altronate dehydratase|multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase|β-D-glucuronidase|2-keto-3-deoxygluconokinase|D-mannonate oxidoreductase|D-mannonate dehydratase|D-altronate dehydratase uxaA|D-glucuronate isomerase / D-galacturonate isomerase
|
D-tagaturonate|D-mannonate|H2O|NAD+|a β-D-glucuronoside|aldehydo-D-galacturonate|D-fructuronate|D-glyceraldehyde 3-phosphate|D-glucopyranuronate|D-altronate|aldehydo-D-glucuronate|2-dehydro-3-deoxy-D-gluconate 6-phosphate|2-dehydro-3-deoxy-D-gluconate|H+|pyruvate|NADH
|
99
|
|
TCA cycle III (animals)
|
PWY66-398
|
2-oxoglutarate dehydrogenase complex E1 dimer, subunit of 2-ketoglutarate dehydrogenase complex|(GDP-forming) succinate-CoA ligase|(ADP-forming) succinyl-CoA ligase|fumarate hydratase|succinate dehydrogenase complex|mitochondrial malate dehydrogenase|cytosolic malate dehydrogenase|mitochondrial aconitate hydratase|2-oxoglutarate dehydrogenase complex, (E2) inner core, subunit of 2-ketoglutarate dehydrogenase complex|isocitrate dehydrogenase (NAD)|citrate synthase
|
fumarate|H2O|a 2-oxoglutarate dehydrogenase E2 protein N6-lipoyl-L-lysine|NAD+|acetyl-CoA|a 2-oxoglutarate dehydrogenase E2 protein N6-S-succinyldihydrolipoyl-L-lysine|2-oxoglutarate|(S)-malate|citrate|CO2|a 2-oxoglutarate dehydrogenase E2 protein N6-dihydrolipoyl-L-lysine|oxaloacetate|D-threo-isocitrate|H+|succinyl-CoA|phosphate|cis-aconitate|succinate|NADH|coenzyme A
|
97
|
|
superpathway of thiamine diphosphate biosynthesis I
|
THISYN-PWY
|
thiamine phosphate synthase|2-iminoacetate synthase, subunit of thiazole synthase|thiamine monophosphate kinase|cysteine desulfurase|L-cysteine desulfurase|ThiS adenylyltransferase|cysteine desulfurase [IscS]2|ThiI|HMP-P synthase|thiamine phosphate synthase thiE|hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase|1-deoxyxylulose-5-phosphate synthase|1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase, subunit of thiazole synthase
|
S-adenosyl-L-methionine|NADPH|an L-cysteine desulfurase-L-cysteine|1-deoxy-D-xylulose 5-phosphate|4-amino-2-methyl-5-(diphosphomethyl)pyrimidine|4-methylphenol|L-cysteine|H2O|NADP+|L-alanine|D-glyceraldehyde 3-phosphate|formate|pyruvate|CO2|5-deoxyadenosine|4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine|L-tyrosine|2-iminoacetate|L-methionine|an L-cysteine desulfurase L-cysteine persulfide|carbon monoxide|diphosphate|thiamine phosphate|H+|2-(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylideneethyl phosphate|thiamine diphosphate
|
96
|
|
superpathway of thiamine diphosphate biosynthesis II
|
PWY-6895
|
thiamine phosphate synthase|thiamine monophosphate kinase|cysteine desulfurase|4-amino-2-methyl-5-phosphomethylpyrimidine kinase|[sulfur-carrier protein ThiS] adenylyltransferase|thiazole tautomerase|phosphomethylpyrimidine synthase|thiazole synthase|1-deoxyxylulose-5-phosphate synthase|thiazole tautomerase tenI|glycine oxidase
|
S-adenosyl-L-methionine|2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate|glycine|an L-cysteine desulfurase-L-cysteine|1-deoxy-D-xylulose 5-phosphate|4-amino-2-methyl-5-(diphosphomethyl)pyrimidine|L-cysteine|H2O|L-alanine|D-glyceraldehyde 3-phosphate|formate|pyruvate|CO2|5-deoxyadenosine|4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine|2-iminoacetate|L-methionine|an L-cysteine desulfurase L-cysteine persulfide|hydrogen peroxide|oxygen|carbon monoxide|diphosphate|thiamine phosphate|H+|2-(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylideneethyl phosphate|thiamine diphosphate
|
96
|
|
sucrose biosynthesis I (from photosynthesis)
|
SUCSYN-PWY
|
N-acetylglucosamine-1-phosphate uridylyltransferase|plastidic phosphoglucose isomerase|chloroplastic fructose-bisphosphate aldolase|UDP-sugar pyrophosphorylase|chloroplastic glyceraldehyde 3-phosphate dehydrogenase|NAD-dependent glyceraldehyde-3-phosphate dehydrogenase|sucrose-phosphate phosphatase|plastidic 3-phosphoglycerate kinase|fructose-1,6-bisphosphatase|UDP-glucose pyrophosphorylase|cytosolic glucose-6-phosphate isomerase|cytosolic 3-phosphoglycerate kinase|sucrose-phosphate synthase|phosphoglucomutase|sucrose phosphate synthase|cytosolic fructose-bisphosphate aldolase
|
H2O|sucrose|NAD+|3-phospho-D-glycerate|D-glucopyranose 6-phosphate|diphosphate|D-glyceraldehyde 3-phosphate|fructose 1,6-bisphosphate|glycerone phosphate|sucrose 6F-phosphate|α-D-glucopyranose 1-phosphate|H+|phosphate|β-D-fructofuranose 6-phosphate|UDP-α-D-glucose|NADH|1,3-bisphospho-D-glycerate
|
96
|
|
superpathway of pentose and pentitol degradation
|
PWY-5257
|
D-arabinonate dehydratase [AraD]8|D-xylose reductase|aldehyde reductase, NADPH-dependent|L-arabinolactonase|L-rhamnose isomerase [RhaA]4|L-arabitol dehydrogenase|KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase|D-arabinonate dehydratase|xylitol dehydrogenase|L-xylulose 5-phosphate 3-epimerase ulaE|L-arabinose reductase|xyulokinase|2-keto-3-deoxyxylonate dehydratase|aldose 1-dehydrogenase [Gdh]4|D-arabinose 1-dehydrogenase [AraDH]4|xylulokinase|L-arabonate dehydratase|L-ribulokinase [AraB]2|KpLE2 phage-like element; D-xylonate dehydratase|aldose 1-dehydrogenase|2-dehydro-3-deoxy-D-arabinonate aldolase [multifunctional] [SSO224174]4|CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase|mannitol dehydrogenase / arabitol dehydrogenase|α-ketoglutarate semialdehyde dehydrogenase|2-dehydro-3-deoxy-D-arabinonate aldolase [multifunctional]|aldehyde dehydrogenase A, NAD-linked [AldA]4|L-2-keto-3-deoxyarabonate dehydratase|L-ribulose 5-phosphate 4-epimerase|L-arabinose isomerase|malate synthase A|L-rhamnose isomerase|malate synthase G|L-xylulose reductase|L-arabinose 1-dehydrogenase|L-ribulose-5-phosphate 4-epimerase|L-xylulose kinase [LyxK]2|aldose reductase|D-xylulokinase|apparent malate synthase|L-arabinose isomerase [AraA]6|L-fuculose-phosphate aldolase|xylulose kinase|aldehyde dehydrogenase A, NAD-linked|D-arabitol dehydrogenase|D-xyulokinase|D-galactitol dehydrogenase / L-arabinitol 4-dehydrogenase|D-xylulose kinase|D-xylose dehydrogenase|NAD+-dependent xylitol dehydrogenase|α-ketoglutaric semialdehyde dehydrogenase|L-xylulose kinase|L-ribulokinase|L-fuculokinase|D-ribulokinase|ribitol dehydrogenase|xylose isomerase|2-keto-3-deoxy-D-arabinonate dehydratase|D-xylonate dehydratase|CP4-6 prophage; D-xylonate dehydratase|L-fucose isomerase|glycolaldehyde oxidoreductase [SSO2637][SSO2636][SSO2639]|L-arabinolactonase araB|D-arabinose 1-dehydrogenase|D-sorbitol dehydrogenase / NAD-xylitol dehydrogenase
|
D-xylulose 5-phosphate|2,5-dioxopentanoate|NADPH|β-L-lyxopyranose|L-arabitol|2-dehydro-3-deoxy-D-arabinonate|D-ribulose 5-phosphate|D-xylonate|H2O|NAD+|acetyl-CoA|D-xylonolactone|D-xylulose|D-arabinono-1,4-lactone|D-arabinonate|NADP+|glyoxylate|glycolaldehyde|glycolate|L-ribulose 5-phosphate|xylitol|pyruvate|D-xylopyranose|L-xylulose|D-ribulose|L-arabinono-1,4-lactone|L-xylulose 5-phosphate|D-arabinopyranose|(S)-malate|D-arabinofuranose|ribitol|L-arabinopyranose|coenzyme A|L-ribulose|2-dehydro-3-deoxy-L-arabinonate|L-arabinonate|L-arabinofuranose|glycerone phosphate|D-arabitol|D-ribulose 1-phosphate|H+|2-oxoglutarate|NADH
|
95
|
|
superpathway of L-lysine degradation
|
PWY-5327
|
α-aminoadipate aminotransferase|L-lysine α-oxidase [L-lysine α-oxidase subunit]2|glutarate semialdehyde dehydrogenase|succinyl-CoA-glutarate CoA-transferase C7orf10|5-aminovalerate transaminase|L-lysine 6-dehydrogenase|3-keto,5-aminohexanoate cleavage enzyme|Δ1-piperideine-6-carboxylate dehydrogenase|α-aminoadipic semialdehyde dehydrogenase|short-chain acyl-CoA dehydrogenase|L-3-aminobutyryl coenzyme A deaminase|Δ1-piperideine-2-carboxylate reductase|L-lysine 2,3-aminomutase|lysine 2,3-aminomutase|lysine racemase|L-lysine monooxygenase [DavB]4|kynurenine/alpha-aminoadipate aminotransferase|L-lysine:pyruvate aminotransferase|3-keto-5-aminohexanoate cleavage enzyme|acetyl-CoA acetyltransferase|L-β-lysine-5,6-aminomutase|N6-acetyllysine aminotransferase|L-erythro-3,5-diaminohexanoate dehydrogenase|L-lysine monooxygenase|acetyl-CoA C-acetyltransferase|phosphate acetyltransferase|lysine decarboxylase 1|succinyl-CoA-glutarate CoA-transferase|L-lysine 6-aminotransferase|D-amino acid oxidase|butyryl-CoA:acetoacetate CoA-transferase|δ-aminovaleramidase davA|lysine decarboxylase|phosphate acetyltransferase / phosphate propionyltransferase|cytosolic acetyl-CoA acetyltransferase|saccharopine dehydrogenase / lysine-ketoglutarate reductase|3,5-diaminohexanoate dehydrogenase|pipecolate oxidase|α-aminoadipic semialdehyde synthase, mitochondrial|lysine N6-acetyltransferase|lysine decarboxylase 2|mitochondrial acetyl-CoA acetyltransferase|α-aminoadipic semialdehyde dehydrogenase [ALDH7A1]4|lysine 5,6-aminomutase|3-aminobutyryl-CoA deaminase|L-α-aminoadipate δ-semialdehyde:NAD oxidoreductase|L-lysine α-oxidase|δ-aminovaleramidase|ketimine reductase mu-crystallin|probable 2-oxoglutarate dehydrogenase E1 component DHKTD1|acetate kinase|L-pipecolate oxidase|lysine ε-aminotransferase|phosphotransacetylase|L-lysine ε-dehydrogenase
|
NADPH|2-oxoadipate|acetyl phosphate|5-aminopentanamide|L-saccharopine|L-β-lysine|1-piperideine 6-carboxylate|ammonium|butanoyl-CoA|crotonyl-CoA|glutaryl-CoA|H2O|1-piperideine-2-carboxylate|NAD+|acetyl-CoA|butanoate|(S)-5-amino-3-oxohexanoate|cadaverine|NADP+|L-alanine|L-glutamate|acetoacetyl-CoA|phosphate|glutarate semialdehyde|pyruvate|CO2|N6-acetyl-L-lysine|acetate|D-lysine|5-aminopentanoate|(S)-3-aminobutanoyl-CoA|(3S,5S)-3,5-diaminohexanoate|L-lysine|glutarate|hydrogen peroxide|2-keto-6-aminocaproate|succinate|oxygen|coenzyme A|L-pipecolate|acetoacetate|2-keto-6-acetamidocaproate|L-2-aminoadipate|(S)-2-amino-6-oxohexanoate|5-acetamidovalerate|H+|succinyl-CoA|2-oxoglutarate|NADH
|
93
|