|
superpathway of pyrimidine ribonucleotides de novo biosynthesis
|
PWY0-162
|
dihydroorotate dehydrogenase, type 2 pyrD|CTP synthase|UMP synthase|UMP kinase|nucleoside diphosphate kinase|dihydroorotase|carbamoyl phosphate synthetase|dihydroorotate dehydrogenase, type 2|orotate phosphoribosyltransferase|aspartate carbamoyltransferase|UMP/CMP kinase|nucleoside-diphosphate kinase 1|aspartate transcarbamylase|CAD protein
|
carbamoyl phosphate|H2O|L-glutamine|hydrogen carbonate|diphosphate|L-aspartate|orotate|L-glutamate|(S)-dihydroorotate|H+|phosphate|5-phospho-α-D-ribose 1-diphosphate|CO2|orotidine 5-phosphate|N-carbamoyl-L-aspartate
|
116
|
|
superpathway of guanosine nucleotides de novo biosynthesis II
|
PWY-6125
|
ribonucleoside-triphosphate reductase, subunit of anaerobic nucleoside-triphosphate reductase activating system|ribonucleoside-triphosphate reductase [NrdD]2|nucleoside diphosphate kinase|ribonucleoside diphosphate reductase 1|guanylate kinase|GMP synthetase|IMP dehydrogenase|ribonucleoside-diphosphate reductase 2
|
H2O|NAD+|L-glutamine|diphosphate|L-glutamate|H+|NADH
|
116
|
|
1,3-propanediol biosynthesis (engineered)
|
PWY-7385
|
glycerol dehydratase|DL-glycerol-3-phosphatase|sugar phosphatase|NADPH-dependent aldehyde reductase [YqhD]2|glucosamine kinase / glucokinase|6-phosphofructokinase I|fructose bisphosphate aldolase class I|glycerol 3-phosphate dehydrogenase|6-phosphofructokinase II|fructose bisphosphate aldolase class II|phosphoglucose isomerase|glycerol-3-phosphate dehydrogenase, biosynthetic|NADPH-dependent aldehyde reductase
|
3-hydroxypropionaldehyde|H2O|NAD+|phosphate|1,3-propanediol|β-D-fructofuranose 6-phosphate|D-glyceraldehyde 3-phosphate|NADP+|glycerone phosphate|fructose 1,6-bisphosphate|H+|sn-glycerol 3-phosphate|NADPH|glycerol|D-glucopyranose 6-phosphate|NADH
|
116
|
|
superpathway of L-alanine biosynthesis
|
PWY0-1061
|
valine-pyruvate aminotransferase avtA|alanine racemase 2, PLP-binding|valine-pyruvate aminotransferase|branched-chain amino-acid aminotransferase|L-cysteine desulfurase|glutamate-pyruvate aminotransferase|alanine racemase 1, PLP-binding, biosynthetic|cysteine desulfurase
|
L-cysteine|3-methyl-2-oxobutanoate|an L-cysteine desulfurase L-cysteine persulfide|2-oxoglutarate|an L-cysteine desulfurase-L-cysteine|L-alanine|L-glutamate|D-alanine|L-valine|pyruvate
|
114
|
|
adenosylcobalamin biosynthesis II (aerobic)
|
P381-PWY
|
precorrin-3B synthase|precorrin-6A reductase|cobaltochelatase [CobN][(CobS)(CobT)]|nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase|CobO|5,6-dimethylbenzimidazole synthase|precorrin-4 (C11)-methyltransferase cobM|L-threonine kinase pduX|precorrin 3B synthase|cobyrinate a,c-diamide synthase [CobB]2|precorrin-8x methylmutase|CobP|adenosyl-cobyric acid synthase|threonine-phosphate decarboxylase|adenosylcobinamide-phosphate synthase|precorrin-5 (C1)-methyltransferase|5,6-dimethylbenzimidazole synthase bluB|uroporphyrin-III methyltransferase|cobaltochelatase|precorrin-4 (C11)-methyltransferase|precorrin-5 (C1)-methyltransferase cobF|precorrin-6B C5,15-methyltransferase|precorrin-2 (C20)-methyltransferase|precorrin-2 (C20)-methyltransferase [CobI]2|precorrin-3B (C17)-methyltransferase|precorrin-8x methylmutase [CobH]2|precorrin-6B C5,15-methyltransferase [CobL]8|cob(II)yrinate a,c-diamide reductase|cobyrinate a,c-diamide synthase|porphobilinogen synthase|precorrin-6A reductase cobK|precorrin-3B (C17)-methyltransferase cobJ
|
precorrin-4|S-adenosyl-L-methionine|NADPH|adenosylcobalamin 5-phosphate|L-glutamine|precorrin-3B|D-erythrose 4-phosphate|cob(I)yrinate a,c-diamide|adenosylcobinamide-GDP|ammonium|precorrin-6B|dialurate|Co2+|H2O|hydrogenobyrinate a,c-diamide|NAD+|L-threonine 3-O-phosphate|PPPi|NADP+|cob(II)yrinate a,c-diamide|precorrin-2|L-glutamate|adenosyl-cobyrinate a,c-diamide|phosphate|adenosyl-cobinamide phosphate|CO2|acetate|preuroporphyrinogen|precorrin-6A|precorrin-5|(S)-4-amino-5-oxopentanoate|precorrin-1|nicotinate|precorrin-7|precorrin-8x|L-threonine|5,6-dimethylbenzimidazole|FMNH2|adenosylcobyrate|(R)-1-amino-2-propanol O-2-phosphate|oxygen|β-nicotinate D-ribonucleotide|α-ribazole 5-phosphate|porphobilinogen|precorrin-3A|hydrogenobyrinate|diphosphate|uroporphyrinogen-III|S-adenosyl-L-homocysteine|riboflavin|H+|5-aminolevulinate|NADH
|
112
|
|
superpathway of L-threonine metabolism
|
THREOCAT-PWY
|
threonine deaminase|acetohydroxy acid isomeroreductase|2-amino-3-ketobutyrate CoA ligase|2-iminobutanoate/2-iminopropanoate deaminase [RidA]3|acetohydroxybutanoate synthase / acetolactate synthase|propionate kinase|catabolic threonine dehydratase|copper-containing amine oxidase [TynA]2|L-threonine kinase|branched-chain amino-acid aminotransferase|L-threonine kinase pduX|low-specificity L-threonine aldolase|copper-containing amine oxidase|2-ketobutyrate formate-lyase / pyruvate formate-lyase 4|threonine dehydrogenase|phosphate acetyltransferase / phosphate propionyltransferase|L-threonine-O-3-phosphate decarboxylase|pyruvate formate-lyase / 2-ketobutyrate formate-lyase|acetolactate synthase / acetohydroxybutanoate synthase|aldehyde-alcohol dehydrogenase|acetaldehyde dehydrogenase 2|acetate kinase|dihydroxy acid dehydratase|L-threonine dehydrogenase
|
NADPH|glycine|hydrogen peroxide|propanoyl phosphate|(R)-2,3-dihydroxy-3-methylpentanoate|ammonium|propanoate|(S)-3-methyl-2-oxopentanoate|H2O|NAD+|methylglyoxal|acetyl-CoA|L-threonine 3-O-phosphate|NADP+|acetaldehyde|L-glutamate|phosphate|formate|pyruvate|CO2|L-threonine|propanoyl-CoA|aminoacetone|L-2-amino-3-oxobutanoate|(2Z)-2-aminobut-2-enoate|oxygen|coenzyme A|L-isoleucine|2-iminobutanoate|(S)-2-aceto-2-hydroxybutanoate|(R)-1-amino-2-propanol O-2-phosphate|2-oxobutanoate|H+|2-oxoglutarate|NADH
|
112
|
|
superpathway of L-aspartate and L-asparagine biosynthesis
|
ASPASN-PWY
|
aspartate ammonia-lyase|asparaginase II|asparagine synthetase A|aspartate ammonia-lyase [AspA]4|asparagine synthetase B|asparaginase I|isoaspartyl dipeptidase / asparaginase III|aspartate aminotransferase, PLP-dependent
|
L-asparagine|fumarate|H2O|diphosphate|L-aspartate|oxaloacetate|L-glutamate|H+|ammonium|2-oxoglutarate
|
112
|
|
peptidoglycan maturation (meso-diaminopimelate containing)
|
PWY0-1586
|
L,D-transpeptidase YcfS|biosynthetic peptidoglycan transglycosylase|peptidoglycan glycosyltransferase - peptidoglycan D,D transpeptidase|D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5|L,D-transpeptidase LdtD|L,D-transpeptidase LdtE|L,D-transpeptidase YbiS|DD-endopeptidase / DD-carboxypeptidase|peptidoglycan glycosyltransferase|peptidoglycan glycosyltransferase / peptidoglycan D,D-transpeptidase|L,D-transpeptidase ErfK
|
H2O|D-alanine|glycine|ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine|a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate) tripeptide|a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide|a mature peptidoglycan with L,D cross-links (meso-diaminopimelate containing)|a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide|a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide|a nascent peptidoglycan with L,D cross links (meso-diaminopimelate containing)|a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate) tripeptide|di-trans,octa-cis-undecaprenyl diphosphate|H+|a nascent peptidoglycan with D,D cross-links (meso-diaminopimelate containing)|a mature peptidoglycan with D,D cross-links (meso-diaminopimelate containing)|a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide
|
109
|
|
superpathway of Clostridium acetobutylicum acidogenic fermentation
|
PWY-6590
|
butyryl-CoA dehydrogenase|3-hydroxybutyryl-CoA dehydrogenase|phosphotransacetylase|3-hydroxybutyryl-CoA dehydratase|pyruvate:ferredoxin oxidoreductase|acetate kinase|acetyl-CoA C-acetyltransferase|phosphotransbutyrylase|butyrate kinase|phosphotransbutyrylase [Ptb]8|(S)-3-hydroxybutyryl-CoA dehydrogenase|butyrate kinase [Buk1]2
|
acetyl phosphate|butanoyl phosphate|acetate|NAD+|acetyl-CoA|butanoate|butanoyl-CoA|acetoacetyl-CoA|H2O|CO2|(S)-3-hydroxybutanoyl-CoA|H+|phosphate|pyruvate|NADH|crotonyl-CoA|coenzyme A
|
109
|
|
superpathway of aromatic compound degradation via 3-oxoadipate
|
PWY-2504
|
4-hydroxy-2-oxovalerate aldolase|β-ketoadipate enol-lactone hydrolase [PcaD]3|2-oxopent-4-enoate hydratase|benzoate 1,2-dioxygenase|β-ketoadipyl CoA thiolase|β-ketoadipate:succinyl CoA transferase [PcaI]2[PcaJ]2|NADP+-benzaldehyde dehydrogenase|3-carboxymuconate cycloisomerase|dehydroshikimate dehydratase|p-hydroxybenzoate hydroxylase|kynureninase|β-ketoadipate enol-lactone hydrolase|catechol 1,2-dioxygenase|quinate/shikimate dehydrogenase|β-ketoadipate:succinyl CoA transferase|muconolactone isomerase|4-carboxymuconolactone decarboxylase [PcaC]6|anthranilate dioxygenase|(S)-mandelate dehydrogenase|2-hydroxymuconic semialdehyde hydrolase|2-oxopent-4-enoate hydratase, subunit of 4-oxalocrotonate/2-oxopent-4-enoate hydratase complex|protocatechuate 3,4-dioxygenase|benzoylformate decarboxylase|mandelate racemase|mandelate racemase mdlA|benzaldehyde dehydrogenase|tryptophan dioxygenase|4-hydroxy-2-ketovalerate aldolase|acylating aldehyde dehydrogenase|acetaldehyde dehydrogenase|catabolic 3-dehydroquinate dehydratase|benzaldehyde dehydrogenase [multifunctional]|1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase [multifunctional]|4-hydroxybenzaldehyde dehydrogenase|2-hydroxymuconic semialdehyde hydrolase xylF|catechol 2,3-dioxygenase|aldehyde dehydrogenase|4-carboxymuconolactone decarboxylase|muconate cycloisomerase|(S)-mandelate dehydrogenase mdlB
|
3-oxoadipyl-CoA|2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate|NADPH|cis,cis-muconate|3-carboxy-cis,cis-muconate|(S)-4-hydroxymandelate|(S)-mandelate|protocatechuate|3-oxoadipate|ammonium|H2O|benzaldehyde|NAD+|acetyl-CoA|3,5-cyclohexadiene-1,2-diol-1-carboxylate|NADP+|L-alanine|acetaldehyde|3-dehydroshikimate|(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate|4-hydroxybenzoate|L-tryptophan|phenylglyoxylate|formate|pyruvate|CO2|4-hydroxybenzaldehyde|benzoate|shikimate|L-kynurenine|3-oxoadipate enol lactone|(R)-mandelate|(R)-4-hydroxymandelate|N-formylkynurenine|succinate|L-quinate|oxygen|coenzyme A|muconolactone|2-(4-hydroxyphenyl)-2-oxoacetate|anthranilate|2-oxopent-4-enoate|4-hydroxy-2-oxopentanoate|3-dehydroquinate|H+|succinyl-CoA|catechol|NADH
|
109
|